Interferon-β therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism

Azoulay, David; Mausner-Fainberg, Karin; Urshansky, Nataly; Fahoum, Firas; Karni, Arnon

doi:10.1016/j.jneuroim.2009.04.004

Cited by 41 publications

(30 citation statements)

References 47 publications

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“…However, interferon-β has previously been demonstrated to affect the T regulatory cell compartment [33] and was reported to induce BDNF secretion in immune cells [34,35]. Therefore, we cannot exclude that pleiotropic ‘beneficial’ interferon effects overlay the potential immunological effects of physical activity.…”

Section: Discussionmentioning

confidence: 96%

Physical Activity in Multiple Sclerosis: A Comparative Study of Vitamin D, Brain-Derived Neurotrophic Factor and Regulatory T Cell Populations

Waschbisch

Wenny

Tallner³

et al. 2012

Eur Neurol

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Background: Previous studies suggest beneficial effects of exercise in multiple sclerosis (MS). However, knowledge on the effects of physical activity on the immune system is limited. Objective: To assess potential relationships between cardiorespiratory fitness, cognitive function, and immune parameters in physically active and inactive MS patients. Methods: We identified 83 patients with relapsing-remitting disease, an unrestricted walking range, and stable interferon-β treatment from our data base. Based on the subjective report of physical activity, the lower/inactive (n = 21) and upper/active quartiles (n = 21) of patients were selected. We assessed the frequency of T cells, B cells, NK cells, monocytes and regulatory T cell populations by flow cytometry, measured brain-derived neurotrophic factor and vitamin D serum levels by ELISA, and conducted spiroergometry and transcranial sonography. Results: Physical activity and cardiorespiratory fitness were not associated with brain-derived neurotrophic factor, frequency of T regulatory cells or any other immune cell subpopulation. However, we found a positive correlation of vitamin D serum levels with cardiorespiratory fitness. Conclusion: Overall, we found no negative effect of physical activity on the immune system. The association between vitamin D and cardiorespiratory fitness most likely reflects longer hours of sunlight exposure in active patients, suggesting a desirable ‘side- effect’ of physical activity.

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Section: Discussionmentioning

confidence: 96%

Physical Activity in Multiple Sclerosis: A Comparative Study of Vitamin D, Brain-Derived Neurotrophic Factor and Regulatory T Cell Populations

Waschbisch

Wenny

Tallner³

et al. 2012

Eur Neurol

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“…BDNF is produced by resident CNS cells, but under inflammatory settings such as in MS, it may be also released by infiltrating immune cells (Stadelmann et al, 2002). Interestingly, BDNF production by peripheral immune cells of MS patients is enhanced upon immunomodulatory therapy (Azoulay et al, 2005(Azoulay et al, , 2008(Azoulay et al, , 2009Sarchielli et al, 2007). Endogenous and immune cellderived BDNF can regulate experimental neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

Colombo¹,

Cordiglieri²,

Melli³

et al. 2012

J Cell Biol

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“…19 Treatment with IFN␤ has been shown to upregulate expression of BDNF. 20,21 Also, nerve growth factor is induced in a dose-dependent manner by IFN␤ 22 and is inversely correlated to MRI measures of axonal loss. 23 Third, IFN␤-1b induces the expression of proteins associated with the inhibition of oxidative stress.…”

Section: Patientsmentioning

confidence: 99%

Interferon β-1b and glatiramer acetate effects on permanent black hole evolution

et al. 2011

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Objective:To compare interferon ␤-1b (IFN␤-1b) and glatiramer acetate (GA) on new lesion (NL) (gadolinium-enhancing, new T2) evolution into permanent black holes (PBH)-a marker of irreversible tissue damage-in patients with relapsing-remitting multiple sclerosis (RRMS).Methods: BEYOND was a large, phase III, clinical trial comparing IFN␤-1b 250 g, IFN␤-1b 500 g, and GA (2:2:1). Patient scans were reexamined post hoc for PBH in a rater-blinded manner. Two predefined coprimary endpoints compared IFN␤-1b 250 g with GA: first, number of PBH per patient at year 2 evolving from year 1 NL, then proportion of year 1 NL evolving into PBH at year 2. IFN␤-1b 500 g and GA were compared in an exploratory fashion.Results: Approximately 90% (1,957/2,244) of patients had NL at year 1 with follow-up at year 2. Mean numbers of PBH per patient at year 2 evolving from year 1 NL were lower for IFN␤-1b 250 g than GA (0.30 vs 0.43; p ϭ 0.0451). The proportion of NL evolving into PBH was similar (IFN␤-1b 250 g vs GA: 21.6% vs 23.5%; p Ͼ 0.20). For IFN␤-1b 500 g, both the mean PBH number per patient at year 2 evolving from year 1 NL (0.26 vs 0.43; p ϭ 0.0037) and proportion of NL evolving into PBH (16.3% vs 23.5%; p ϭ 0.0409) were lower relative to GA.

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Interferon-β therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism

Cited by 41 publications

References 47 publications

Physical Activity in Multiple Sclerosis: A Comparative Study of Vitamin D, Brain-Derived Neurotrophic Factor and Regulatory T Cell Populations

Physical Activity in Multiple Sclerosis: A Comparative Study of Vitamin D, Brain-Derived Neurotrophic Factor and Regulatory T Cell Populations

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

Interferon β-1b and glatiramer acetate effects on permanent black hole evolution

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