Interferon-γ and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation

Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region

“…[4][5][6][7] Although IFNg is known to play an important role in antiparasitic host defence as well as the pathogenesis of severe malaria, 11 we found no evidence of association between this microsatellite and susceptibility to severe malaria. However, this does not rule out an association between malaria and genetic determinants of IFNg production, as published studies of association between the microsatellite and IFNg production have been performed mainly in Caucasian individuals, 3 as were the data showing extremely strong correlation between the 12 CA-repeat allele and the IFNG þ 874T allele, which is located at a putative binding site for the transcription factor NF-kB.…”

“…1,2 Several studies have reported associations between IFNG polymorphisms and susceptibility to disease. The first intron of the IFNG gene contains a highly polymorphic CA-repeat microsatellite, whose 12 CA-repeat allele is associated with high levels of IFNg production in vitro 3 and has been associated with resistance or susceptibility to various diseases including rheumatoid arthritis, 4 allograft fibrosis in lung transplant recipients, 5 acute graft-versus-host disease 6 and asthma. 7 This microsatellite allele has been associated with a singlenucleotide polymorphism (SNP) allele IFNG þ 874T, which coincides with a putative NF-kB binding site, 8 and has been associated with resistance to tuberculosis.…”

Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation: a single-center experience

“…Other studies concerning IL-10 gene polymorphisms have shown conflicting results: some suggesting that a genotype relative to low production of IL-10 correlates with an increased risk of aGVHD 19,20 and others outlining an association between high producer genotype and acute or chronic GVHD. 7 In a large cohort of HLA-matched sibling transplants, the presence of the IL-10 ATA/ACC genotype in the recipient has been associated with a moderate risk of GVHD and lower risk of death in remission, 16 more severe GVHD occurring in groups without the IL-10 ATA haplotype.…”

Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used

“…[1][2][3]12 Several studies have reported associations between IL-10 promoter polymorphisms and risk of a diverse range of diseases including (for example) asthma, systemic lupus erythematosus and rheumatoid arthritis, infectious diseases as well as transplantation complications. [13][14][15][16][17][18][19][20][21][22][23][24][25] These results, coupled with recent data indicating a relationship between distal haplotypes in the same region and IL-10 production have raised the possibility that other more distal promoter elements may affect IL-10 production.…”