Interferon-γ (IFN-γ) as In Vitro Enhancing Factor of Peritoneal Macrophage Defective Bactericidal Activity During Continuous Ambulatory Peritoneal Dialysis (CAPD)

Lamperi, S; Carozzi, S

doi:10.1016/s0272-6386(88)80154-9

Cited by 35 publications

(9 citation statements)

References 17 publications

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“…Also, the PMf from such patients are less efficient in generating and in killing S. epidermidis, and they display a reduced membrane Fc receptor number. These findings are in accord with the results of previous studies showing that peritoneal cells from these patients do not function as well as those obtained from patients with a low incidence of peritonitis (15); however, they conflict with those of others (9) who found the peritoneal immune cell functions in patients undergoing CAPD to be near normal, without taking into account the frequency of peritonitis in such patients. We found that PLy and PM4 taken from high-peritonitisincidence CAPD patients, when incubated in vitro with increasing concentrations of MPL, are able to regain a satisfactory ability to release cytokines.…”

Section: Discussionsupporting

confidence: 86%

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Effect of monophosphoryl lipid A on the in vitro function of peritoneal leukocytes from uremic patients on continuous ambulatory peritoneal dialysis

Carozzi¹,

Salit²,

Cantaluppi³

et al. 1989

J Clin Microbiol

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We analyzed the effects of monophosphoryl lipid A (MPL), a relatively nontoxic immunostimulant derived from bacterial endotoxin, on the depressed in vitro immune function of leukocytes derived from six patients undergoing continuous ambulatory peritoneal dialysis and who had histories of recurrent bacterial peritonitis. MPL was also tested for its capacity to stimulate the proliferation of peritoneal fibroblasts, as determined by [3H]thymidine incorporation. In vitro incubation of peritoneal lymphocytes and macrophages (PM+) with increasing amounts of MPL, up to 5 ,ug/ml, resulted in a dose-dependent enhancement of gamma interferon and interleukin-2 production by peritoneal lymphocytes and interleukin-1 release by PMq. In vitro incubation of PM4 with MPL also resulted in an increase of PMc bacterial killing and membrane Fc receptor number, although no change in peritoneal fibroblast proliferation was seen with any of the MPL concentrations tested. These results suggest that the peritoneal leukocyte dysfunction observed in patients undergoing continuous ambulatory peritoneal dialysis and who have high rates of peritonitis may be alleviated, to some degree, by MPL, without directly inducing a potentially deleterious fibrotic lesion.

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Section: Discussionsupporting

confidence: 86%

“…This is accompanied by an increase in the number of PMX Fc receptors and in PMX bactericidal capacity. This effect of MPL on peritoneal immune cell functions has some analogy with that observed in animals and humans seen by incubating PM4X with IFN-y (12,15,29).…”

Section: Discussionsupporting

confidence: 61%

Effect of monophosphoryl lipid A on the in vitro function of peritoneal leukocytes from uremic patients on continuous ambulatory peritoneal dialysis

Carozzi¹,

Salit²,

Cantaluppi³

et al. 1989

J Clin Microbiol

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“…Lower amounts of IFN‐ γ released by peritoneal lymphocytes from PD patients with high peritonitis incidence in comparison with patients with low peritonitis incidence and healthy people has been reported by Lamperi et al . [40]. The bacterial killing of peritoneal macrophages improved after treatment with IFN‐ γ .…”

Section: Discussionmentioning

confidence: 99%

Children with chronic renal failure have reduced numbers of memory B cells

Bouts

Davin

Krediet

et al. 2004

Clinical and Experimental Immunology

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SUMMARYReduced serum IgG and subclass levels have been demonstrated in children with chronic renal failure. To study possible causes of this reduction, we analysed B cell subset composition, T helper cell frequencies and immunoglobulin (Ig) production capacity in vitro in children with chronic renal failure, with or without dialysis treatment. B cell subsets were characterized by determining CD27, IgM, IgD and CD5 expression within the CD19 CD27+ lymphocytes) were lower in children treated with haemodialysis (HD), peritoneal dialysis (PD) and children with chronic renal failure before starting dialysis treatment (CRF) compared to healthy controls (HC) ( P < 0·05). Compared with HC, CD5 + (naive) B cells were reduced in HD-treated patients but not for PD or for children with chronic renal failure before starting dialysis treatment (CRF). No significant differences in CD4 + T helper cell subsets were found between the groups. However, CRF children had a higher percentage of IFN-g producing CD8 +T lymphocytes compared to HC ( P = 0·02). Finally, IgG 1 , IgG 2 and IgM production in vitro was similar in the four groups. In conclusion, significantly lower numbers of memory type B cells were found in children with chronic renal failure compared to healthy controls. This reduction may contribute to the low Ig levels found in these children.

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“…Previous reports described that peritonitis in PD patients is predominantly a type 1 immune response characterized by the early induction of TNF-α, IL-1β, IL-12, and IL-18, followed by elevated levels of IFN-γ [ 2 , 38 ]. The presence of a Th1 phenotype in peritoneal effluents seems to lower the risk of peritonitis [ 4 , 20 ]. These findings suggested that peritoneal Th1 cells may improve cooperation among T cells, peritoneal macrophages, and peritoneal mesothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Th2-biased GATA-3 transgenic mice developed severe experimental peritoneal fibrosis compared with Th1-biased T-bet and Th17-biased RORγt transgenic mice

2015

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Encapsulating peritoneal sclerosis is one of the most serious complications of long-term peritoneal dialysis. The pathogenesis of encapsulating peritoneal sclerosis has not been elucidated, but several putative factors necessary for the development of peritoneum fibrosis (PF) have been reported. However, the roles of T helper (Th) cells in the progression of PF are unknown. The purpose of this study was to clarify the roles of Th1, Th2, and Th17 cells in the progression of PF. T-bet, GATA-3, and RORγt are Th1, Th2, and Th17 lineage commitment transcription factors, respectively. We previously generated Th1-biased (T-bet transgenic (Tg)) mice, Th2-biased (GATA-3 Tg) mice, and Th17-biased (RORγt Tg) mice. In this study, Th1, Th2, Th17-biased, and wild-type mice were administered chlorhexidine gluconate (CG) intraperitoneally and analyzed on day 21. CG-injected GATA-3 Tg mice showed a distended intestinal tract and developed marked thickening of the submesothelial space compared with the other groups. CG-injected GATA-3 Tg mice also showed significant expression of α-SMA positive cells, macrophages, and collagen III in the submesothelium. In contrast, CG-injected T-bet Tg mice only developed mild peritoneal fibrosis. Cytokines analysis in peritoneal fluid showed that IFN-γ was significantly increased in CG-injected T-bet Tg mice and that IL-13 was significantly increased in CG-injected GATA-3 Tg mice. Moreover, intraperitoneal administration of IFN-γ improved PF in GC-injected wild-type mice. Our results suggest that Th2 cells may play roles in the development of experimental PF and that Th1 cells may alleviate the severity of experimental PF.

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Interferon-γ (IFN-γ) as In Vitro Enhancing Factor of Peritoneal Macrophage Defective Bactericidal Activity During Continuous Ambulatory Peritoneal Dialysis (CAPD)

Cited by 35 publications

References 17 publications

Effect of monophosphoryl lipid A on the in vitro function of peritoneal leukocytes from uremic patients on continuous ambulatory peritoneal dialysis

Effect of monophosphoryl lipid A on the in vitro function of peritoneal leukocytes from uremic patients on continuous ambulatory peritoneal dialysis

Children with chronic renal failure have reduced numbers of memory B cells

Th2-biased GATA-3 transgenic mice developed severe experimental peritoneal fibrosis compared with Th1-biased T-bet and Th17-biased RORγt transgenic mice

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