2004
DOI: 10.1016/s0002-9440(10)63241-5
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Interferon-γ Protects against Chronic Viral Myocarditis by Reducing Mast Cell Degranulation, Fibrosis, and the Profibrotic Cytokines Transforming Growth Factor-β1, Interleukin-1β, and Interleukin-4 in the Heart

Abstract: Inflammatory fibrosis is a characteristic feature of myocarditis, dilated cardiomyopathy (DCM), and congestive heart failure. Th1-type immune responses, mediated by interleukin (IL)-12-induced interferon (IFN)-gamma, are believed to exacerbate autoimmune diseases including myocarditis. In this study, we examined the effect of IL-12R beta 1 and IFN-gamma deficiency on the development of chronic CB3-induced myocarditis using knockout mice. We found increased chronic CB3-induced myocarditis (14.1 to 43.1%, P < 0.… Show more

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Cited by 178 publications
(222 citation statements)
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“…In this model, virus replicates at relatively low levels in the heart during acute myocarditis (10 2 -10 4 PFU) compared with other CVB3-induced models (10 7 -10 9 PFU) [8][9][10][11]18,19]. By day 14 pi, infectious virus is cleared from the heart and does not reactivate during chronic myocarditis [6,15]. In genetically susceptible mice a diffuse, lymphocytic infiltrate develops around day 35 pi with large areas of necrosis and fibrosis (Fig.…”
Section: Introductionmentioning
confidence: 87%
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“…In this model, virus replicates at relatively low levels in the heart during acute myocarditis (10 2 -10 4 PFU) compared with other CVB3-induced models (10 7 -10 9 PFU) [8][9][10][11]18,19]. By day 14 pi, infectious virus is cleared from the heart and does not reactivate during chronic myocarditis [6,15]. In genetically susceptible mice a diffuse, lymphocytic infiltrate develops around day 35 pi with large areas of necrosis and fibrosis (Fig.…”
Section: Introductionmentioning
confidence: 87%
“…3B) and DCM (Fig. 3D) [15]. Although viral genome can be detected in heart tissue during chronic myocarditis, persistent virus is found in both susceptible and resistant strains of mice [13,22].…”
Section: Introductionmentioning
confidence: 90%
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