The history of the dark matter problem can be traced back to at least the 1930s, but it was not until the early 1970s that the issue of 'missing matter' was widely recognized as problematic. In the latter period, previously separate issues involving missing mass were brought together in a single anomaly. We argue that reference to a straightforward 'accumulation of evidence' alone is inadequate to comprehend this episode. Rather, the rise of cosmological research, the accompanying renewed interest in the theory of relativity and changes in the manpower division of astronomy in the 1960s are key to understanding how dark matter came to matter. At the same time, this story may also enlighten us on the methodological dimensions of past practices of physics and cosmology.Uncovering the nature of 'dark matter'-the mysterious substance that dominates the mass budget of the universe from sub-galactic to cosmological scales-is arguably one of the greatest challenges of modern physics and cosmology. Indeed, many physicists and astronomers across the world are today trying to identify the nature of dark matter.