Intergenerational transmission of ancestry information in a mid-size city in Argentina

Mendoza, Marcela; Mazza, Bárbara; Cabana, Graciela S.; Smith, L.P.; Rocca, Francisco Di Fabio; Delfino, Hugo; Martínez, Carla

doi:10.1080/17442222.2022.2120730

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Custodians and oversight committees should consider whether to DNA test tissues of unknown provenance to determine their biological ancestry, which may assist in identifying ancestral communities (Gibbon et al, 2023). DNA testing is one method that may be useful in determination of provenance, and its use must be considered in balance against other valid forms of information gathering in the determination of origin (Mendoza et al, 2023). This is because testing DNA may be cost prohibitive.…”

Section: Recommendations For the Management Of Legacy Anatomical Coll...mentioning

confidence: 99%

American Association for Anatomy recommendations for the management of legacy anatomical collections

Cornwall,

Champney,

de la Cova

et al. 2024

The Anatomical Record

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Collections of human remains in scientific and private institutions have a long tradition, though throughout history there has often been variable regard for the respect and dignity that these tissues demand. Recent public scandals around the use of human remains, coupled with an increasing community awareness around accountability in such instances, forces scholars to confront the ethical and moral concerns associated with these collections. This includes specific focus on the acquisition, storage, use, and disposition of these remains, which were often collected with no consent and with little knowledge, or concern, about the individual or their respective culture and practices surrounding death and postmortem treatment. As a response, the American Association for Anatomy convened a Legacy Anatomical Collections Task Force to consider these issues and to develop recommendations to assist those working with these tissues in education, research, and museum collections. This has culminated with the development of Recommendations for the Management of Legacy Anatomical Collections. The recommendations provide both an ethical foundation and practical considerations for the use, storage, and disposition of legacy collections of human tissues, and deliver guidance for establishing appropriate management and oversight, investigating provenance, and engaging with communities of care. While these Recommendations are considered a living document which will change over time as ethical principles concerning human tissue evolve, they currently represent ‘best practice’ recommendations that can guide researchers, teachers, and museum associates as they consider the future of legacy anatomical collections in their care.

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Section: Recommendations For the Management Of Legacy Anatomical Coll...mentioning

confidence: 99%

American Association for Anatomy recommendations for the management of legacy anatomical collections

Cornwall,

Champney,

de la Cova

et al. 2024

The Anatomical Record

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“…The study employed a multi-method research design through the generation, analysis, and interpretation of genomic and ethnographic data in a mid-size city in the province of Buenos Aires, Argentina. Over that period, our research team conducted genetic ancestry analyses, ethnographic interviews, and participant observation (Mendoza and Cabana, 2019;Cabana et al, 2022;Mendoza et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

BAG

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Several population studies showed an association between variation in pain sensitivity and genetic polymorphisms located in Prodynorphin (PDYN) and Kappa Opioid Receptor (OPRK1) human genes. We analysed polymorphisms of these two genes to characterise their variation in Argentinian populations, as well as to evaluate their association with acute pain sensitivity. We studied 11 genetic markers in individuals from four locations in Argentina

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IMPACT OF GENETIC ANCESTRY ON THE DISTRIBUTION OF INTERFERON-λ4 RS12979860 POLYMORPHISM IN a GLOBAL POPULATION OF BUENOS AIRES, ARGENTINA

Mansilla

Avena

Dejean

et al. 2022

BAG

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Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have suffered a positive selection pressure throughout the evolutionary history of the genus Homo. An intronic variant within the IFNλ4 locus (rs12979860, T˃C) emerged as one of the main gene determinants of the response to HCV and other viruses. The rs12979860-C allele has a differential frequency in African, European and Native American populations, though South American data are scarce. Here we characterize for the first time the distribution of rs12979860 genotypes in a sample of the global population of Buenos Aires, Argentina, assessing its association with European, Native American and African parental components. The rs12979860 genotypes were determined by PCR-RFLP in DNA samples from donors of a blood banks of Buenos Aires (n=96), whose genetic individual ancestry (European, African or Native American) had been previously determined using molecular markers. The distribution of rs12979860-CC, CT and TT was 29.17%, 50.0% and 20.83%, respectively. A significant increase in the frequency of CC among donors with a strong European contribution and a greater impact of the Native American component among donors carrying the T allele were observed. Native American and European components were associated to the rs12979860 distribution in a sample of the global population of Buenos Aires, while no differences were directly attributable to the African ancestry. Considering interferon´s key role in antiviral responses, our results may contribute to both bioanthropological and immunogenetic studies associated with infectious diseases. Key words: ancestry, Buenos Aires, IFNλ4 polymorphism, rs12979860 distribution.

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Intergenerational transmission of ancestry information in a mid-size city in Argentina

Cited by 4 publications

References 44 publications

American Association for Anatomy recommendations for the management of legacy anatomical collections

American Association for Anatomy recommendations for the management of legacy anatomical collections

Untitled

IMPACT OF GENETIC ANCESTRY ON THE DISTRIBUTION OF INTERFERON-λ4 RS12979860 POLYMORPHISM IN a GLOBAL POPULATION OF BUENOS AIRES, ARGENTINA

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