Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings

Constant-Varlet, Charlotte; Nakai, Tomoya; Prado, Jérôme

doi:10.1007/s00429-024-02804-5

Brain Struct Funct

2024

DOI: 10.1007/s00429-024-02804-5

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Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings

Charlotte Constant-Varlet,

Tomoya Nakai,

Jérôme Prado

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2024

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Cited by 1 publication

References 85 publications

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Parent-offspring brain similarity: Specificities and commonalities across gender combinations - the Transmit Radiant Individuality to Offspring (TRIO) study

Matsudaira,

Yamaguchi,

Taki

2024

Preprint

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Research suggests that parent-offspring brain similarities may underlie intergenerational transmission of psychopathology. However, most studies have focused on mothers and offspring, with few including fathers. This study aimed to extend understanding of parent-offspring neural similarities by examining parent-offspring trios. The study included 152 Japanese biological parent-offspring trios who participated in the Transmit Radiant Individuality to Offspring (TRIO) study. We analyzed the parent-offspring similarities in brain structural features (cortical thickness, surface area, local gyrification index, and subcortical volume) across different parent-offspring gender combinations (father-son, father-daughter, mother-son, and mother-daughter). Additionally, we investigated the relationship between brain similarities and similarities in intelligence and personality traits in parents and offspring. Our findings confirmed that correlations in brain structural features between father-offspring or mother-offspring dyads were significantly stronger than those between unrelated individuals. Notably, both sons and daughters exhibited brain regions similar to their fathers only, mothers only, both parents, or neither parent. Furthermore, a significant association was observed between similarities in general intelligence and the surface area of auditory regions in both father-offspring and mother-offspring dyads. These results provide valuable insights into the genetic and environmental factors influencing brain development and aging across generations. This study is expected to contribute to future research elucidating the mechanisms underlying the intergenerational transmission of psychiatric disorders.

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Parent-offspring brain similarity: Specificities and commonalities across gender combinations - the Transmit Radiant Individuality to Offspring (TRIO) study

Matsudaira,

Yamaguchi,

Taki

2024

Preprint

View full text Add to dashboard Cite

show abstract

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Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings

Cited by 1 publication

References 85 publications

Parent-offspring brain similarity: Specificities and commonalities across gender combinations - the Transmit Radiant Individuality to Offspring (TRIO) study

Parent-offspring brain similarity: Specificities and commonalities across gender combinations - the Transmit Radiant Individuality to Offspring (TRIO) study

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