Intergenerational transmission of depression: clinical observations and molecular mechanisms

Sawyer, Kristi; Zunszain, Patricia A.; Dazzan, Paola; Pariante, Carmine M.

doi:10.1038/s41380-018-0265-4

Cited by 87 publications

(63 citation statements)

References 235 publications

(244 reference statements)

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“…To our knowledge, this is the first application of the M‐GCTA technique to examine parental genetic effects on mental health outcomes, as the method has previously only been applied to study physical characteristics such as birth length and weight (Eaves et al, 2014; Horikoshi et al, 2016; Qiao et al, 2019). Furthermore, much of the research investigating parental contribution to offspring internalizing problems in childhood has primarily focused on mothers (Sawyer, Zunszain, Dazzan, & Pariante, 2018), even though paternal factors also exert an influence on offspring behavior. This study pays equal attention to the contribution of maternal and paternal influences.…”

Section: Discussionmentioning

confidence: 99%

Maternal and paternal effects on offspring internalizing problems: Results from genetic and family‐based analyses

Jami

Eilertsen

Qiao

et al. 2020

American J of Med Genetics Pt B

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It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the genes transmitted from parent to child. In this study, these effects were investigated using two innovative methods in a large birth cohort. Using maternal-effects genome complex trait analysis (M-GCTA), the effects of offspring genotype, maternal or paternal genotypes, and their covariance on offspring internalizing problems were estimated in 3,801 mother-fatherchild genotyped trios. Next, estimated genetic correlations within pedigree data, including 10,688 children, were used to estimate additive genetic effects, maternal and paternal genetic effects, and a shared family effect using linear mixed effects modeling. There were no significant maternal or paternal genetic effects on offspring anxiety or depressive symptoms at age 8, beyond the effects transmitted via the genetic pathway between parents and children. However, indirect maternal genetic effects explained a small, but nonsignificant, proportion of variance in childhood depressive symptoms in both the M-GCTA (~4%) and pedigree (~8%) analyses. Our results suggest that parental effects on offspring internalizing problems are predominantly due to transmitted genetic variants, rather than the indirect effect of parental genes via the environment.

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Section: Discussionmentioning

confidence: 99%

Maternal and paternal effects on offspring internalizing problems: Results from genetic and family‐based analyses

Jami

Eilertsen

Qiao

et al. 2020

American J of Med Genetics Pt B

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“…Over the last few decades, inflammation has been identified as one of the main pathophysiological mechanisms underlying psychiatric conditions (1,2). Indeed, over-expression of distinct pro-inflammatory cytokines, including interleukin 1 beta (IL-1β), IL-6, and tumor necrosis factor alpha (TNF-α), has been associated with several neuropsychiatric disorders, such as depression (3,4), as well as neurodegenerative diseases, like Alzheimer's (AD) and Parkinson's (PD) (5,6). In particular, patients with major depressive disorder (MDD) exhibit both increased immune activation and aberrant regulation of brain plasticity (7), which has been linked with abnormal cellular immunity (8).…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

et al. 2020

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Inflammation has been identified as one of the main pathophysiological mechanisms underlying neuropsychiatric and neurodegenerative disorders. Despite the role of inflammation in those conditions, there is still a lack of effective anti-inflammatory therapeutic strategies. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) can reduce depressive symptoms and exert anti-inflammatory action putatively by the production of distinct n-3 PUFA-derived metabolites, such as resolvins D (RvD) and E (RvE) series, maresins (MaR) and protectins (PD), which are collectively named specialized pro-resolving mediators (SPMs) and act as strong anti-inflammatory agents. In this review we summarize evidence showing the effects of treatment with those metabolites in pre-clinical models of psychiatric, neurodegenerative and neurological disorders. A total of 25 pre-clinical studies were identified using the PubMed database. Overall, RvD and RvE treatment improved depressive-like behaviors, whereas protectins and maresins ameliorated neurological function. On a cellular level, RvDs increased serotonin levels in a model of depression, and decreased gliosis in neurodegenerative disorders. Protectins prevented neurite and dendrite retraction and apoptosis in models of neurodegeneration, while maresins reduced cell death across all studies. In terms of mechanisms, all SPMs down-regulated pro-inflammatory cytokines. Resolvins activated mTOR and MAP/ERK signaling in models of depression, while resolvins and maresins activated the NF-κB pathway in models of neurodegeneration and neurological disorders. Our review indicates a potential promising approach for tailored therapy with n-3 PUFAs-derived metabolites in the treatment of psychiatric, neurodegenerative, and neurological conditions.

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“…Indeed, a wide array of biological, social and environmental factors have acquired a lot of attention as potential links explaining the association between maternal psychopathologies and child development (Sawyer et al, 2018). Great emphasis has been given to biological changes occurring during the gestational period, with particular focus on those associated with perinatal stress.…”

Section: Introductionmentioning

confidence: 99%

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Benedetto

Bottanelli

Cattaneo

et al. 2020

Brain, Behavior, and Immunity

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Perinatal psychopathologies affect more than 25% of women during and after their gestational period. These psychiatric disorders determine important biological variations in their organisms, affecting many different physiological and metabolic pathways. Of relevance, any of these changes occurring in the mother can alter the normal composition of breast milk, particularly the concentration of nutritional and inflammatory components, which play a role in child brain functioning and development. Indeed, there is evidence showing that changes in milk composition can contribute to cognitive impairments and alterations in mental abilities in children. This review aims to shed light on the unique intergenerational role played by breast milk composition, from maternal psychopathologies to child development.

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Intergenerational transmission of depression: clinical observations and molecular mechanisms

Cited by 87 publications

References 235 publications

Maternal and paternal effects on offspring internalizing problems: Results from genetic and family‐based analyses

Maternal and paternal effects on offspring internalizing problems: Results from genetic and family‐based analyses

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

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