Intergenerational transmission of stress-related epigenetic regulation

Collins, Nicholas; Roth, Tania L.

doi:10.1016/b978-0-12-819262-7.00007-6

Cited by 4 publications

(2 citation statements)

References 86 publications

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“…The relationship between nutritional deprivation during pregnancy, fetal development and subsequent pathology was studied in a "natural experiment" caused by the famine in the Netherlands during World War II. The evolution of children born during this period, followed for 60 years, showed lasting epigenetic changes and a pathology centered on obesity, cardiovascular diseases, depression or schizophrenia (23)(24)(25). In people who endured periods of severe stress in childhood, there was an increase in methylation of the RC gene, a decrease in gene expression in the hippocampus and an increase in the incidence of psychiatric disorders.…”

Section: Maternal Stress During Pregnancymentioning

confidence: 99%

Untitled

2021

Ro J Pediatr.

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During childhood, 3 levels of stress were proposed: positive, tolerable and toxic. The toxic stress produced by the strong, frequent and prolonged activation of the body's response systems is a generator of behavioral and somatic sequelae. Child abuse is present in all social media in different countries. The absence of basic care has devastating effects on social and cognitive development, as found in institutionalized children. Attachment behavior and fear memory are considered stress-related biological systems. The response to stress is driven by the dynamics of cortisol secretion and its interaction with its cellular receptor. It plays a central role in the response to aggression through the process of methylation, decreased gene expression in the hippocampus and increased response to stress. Stress treatment is variable in efficiency and involves preventive measures (family and community), at school, bullying, psychological counseling, trauma-focused psychotherapy, cognitive therapy, through music.

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Section: Maternal Stress During Pregnancymentioning

confidence: 99%

Untitled

2021

Ro J Pediatr.

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“…In short, transgenerational inheritance is only said to occur when the epigenetic marker is present in the first exposure-free generation to the original stressor; this criterion ensures that epigenetic markers are transmitted. For the above reasons, preconception trauma in women, fetoplacental interactions, and improper parental care are considered to be intergenerational inheritance [41] and shall not be confused with the transgenerational inheritance of trauma, as in these scenarios the subject of interest receives direct traumatic experience. The concept of transgenerational, preconceptional, and fetoplacental inheritance is illustrated in Figure 1.…”

Section: Intergenerational and Transgenerational Inheritance Of Epige...mentioning

confidence: 99%

Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder

Chou,

Huang,

2024

Life

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Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes debilitating functional impairment in patients. Observations from survivors of traumatic historical events solidify that this disease is not only associated with personal experiences but can also be inherited from familial traumas. Over the past decades, researchers have focused on epigenetic inheritance to understand how responses to adverse experiences can be passed down to future generations. This review aims to present recent findings on epigenetic markers related to PTSD and research in the intergenerational inheritance of trauma. By understanding the information, we hope that epigenetic markers can act as biochemical measurements for future clinical practice.

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Acculturating Systems of Care to Ensure Healthy Futures for Latine Migrant Youth

Carter

2024

Child and Adolescent Psychiatric Clinics of North America

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Intergenerational transmission of stress-related epigenetic regulation

Cited by 4 publications

References 86 publications

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Untitled

Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder

Acculturating Systems of Care to Ensure Healthy Futures for Latine Migrant Youth

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