Interhemispheric connections of somatosensory cortex in the flying fox

Krubitzer, Leah; Clarey, Janine C.; Tweedale, Rowan; Calford, Michael B.

doi:10.1002/(sici)1096-9861(19981228)402:4<538::aid-cne7>3.0.co;2-t

Cited by 47 publications

(11 citation statements)

References 79 publications

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“…In addition, glutamate levels in left and right SII seem to be a predictor of response to rTMS treatment. Although in our study rTMS was applied only to right SII, we observed changes also in the left SII that were potentially induced directly by transcallosal connections or indirectly via thalamic circuitry as suggested by previous studies (Blankenburg et al, 2008;Krubitzer et al, 1998).…”

Section: 2supporting

confidence: 47%

Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain

Fregni

Potvin

Dasilva

et al. 2011

European Journal of Pain

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Background & Aims-Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment. It has been shown that chronic visceral inflammation, through altered afferent visceral sensory input, leads to plastic changes in the central nervous system that ultimately sustain pain. Therefore approaches aiming at modulation of brain activity are attractive candidates to control visceral pain.

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Section: 2supporting

confidence: 47%

Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain

Fregni

Potvin

Dasilva

et al. 2011

European Journal of Pain

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“…However, other study suggests that nociceptive information reaches distinct thalamic subnuclei eliciting a bilateral cortical response (Tsuji et al 2006). Interhemispheric connections of the primary somatosensory cortex are reported in rodents and monkeys (Iwamura et al 1994;Krubitzer et al 1998). In support of an interhemispheric transfer of sensory information, neurons with bilateral receptive fields of the hands in monkeys, were not present following contralateral lesioning of the postcentral gyrus (Iwamura et al 1994).…”

Section: Activation In the Somatosensory Regionmentioning

confidence: 95%

Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

et al. 2008

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Using Diffuse Optical Tomography (DOT) we detected activation in the somatosensory cortex and frontal brain areas following tactile (brush) and noxious heat stimulation. Healthy volunteers received stimulation to the dorsum of the right hand. In the somatosensory cortex area, tactile stimulation produced a robust, contralateral to the stimulus, hemodynamic response with a weaker activation on the ipsilateral side. For the same region, noxious thermal stimuli produced bilateral activation of similar intensity that had a prolonged activation with a two-peak similar to results have been reported with functional MRI. Bilateral activation was observed in the frontal areas, oxyhemoglobin changes were positive for brush stimulation while they were initially negative (contralateral) for heat stimulation. These results suggest that based on the temporal and spatial characteristics of the response in the sensory cortex, it is possible to discern painful from mechanical stimulation using DOT. Such ability might have potential applications in a clinical setting in which pain needs to be assessed objectively (e.g. analgesic efficacy, pain responses during surgery).

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“…Injection sites included the dense core of label at the center of the site as well as the halo of cells around the site. A detailed account of injection site identification has been previously described (Krubitzer et al, 1998). The full extent of the area containing axon terminals was plotted but the density of the terminals was not measured and in many cases was not uniform in density across the entire area.…”

Section: Methodsmentioning

confidence: 99%

What are the effects of severe visual impairment on the cortical organization and connectivity of primary visual cortex?

et al. 2009

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The organization and connections of the primary visual area (V1) were examined in mice that lacked functional rods (Gnat−/−), but had normal cone function. Because mice are nocturnal and rely almost exclusively on rod vision for normal behaviors, the Gnat−/− mice used in the present study are considered functionally blind. Our goal was to determine if visual cortex is reorganized in these mice, and to examine the neuroanatomical connections that may subserve reorganization. We found that most neurons in V1 responded to auditory, or some combination of auditory, somatosensory, and/or visual stimulation. We also determined that cortical connections of V1 in Gnat−/− mice were similar to those in normal animals, but even in normal animals, there is sparse input from auditory cortex (AC) to V1. An important observation was that most of the subcortical inputs to V1 were from thalamic nuclei that normally project to V1 such as the lateral geniculate (LG), lateral posterior (LP), and lateral dorsal (LD) nuclei. However, V1 also received some abnormal subcortical inputs from the anterior thalamic nuclei, the ventral posterior, the ventral lateral and the posterior nuclei. While the vision generated from the small number of cones appears to be sufficient to maintain most of the patterns of normal connectivity, the sparse abnormal thalamic inputs to VI, existing inputs from AC, and possibly abnormal inputs to LG and LP may be responsible for generating the alterations in the functional organization of V1.

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Interhemispheric connections of somatosensory cortex in the flying fox

Cited by 47 publications

References 79 publications

Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain

Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain

Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

What are the effects of severe visual impairment on the cortical organization and connectivity of primary visual cortex?

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