Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy

Zhao, Xu; Hj, Kang; Zhou, Zhiqiang; Hu, Ying; Li, Juan; Li, Shihui; Li, Jia; Zhu, Wenzhen

doi:10.1002/brb3.2484

Cited by 10 publications

(5 citation statements)

References 49 publications

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“…Prior work has shown that lTLE patients exhibit reduced VMHC values in the MTG, bilateral medial superior frontal gyrus, bilateral inferior parietal lobule, and supplementary motor area ( 33 ). Zhao et al ( 34 ) observed significant reductions in the bilateral MTG connectivity in lTLE patients, in line with the VMHC results from the present study. The inferior temporal gyrus (ITG) and superior temporal gyrus (STG) are, respectively, located on the dorsal and ventral sides of the MTG.…”

Section: Discussionsupporting

confidence: 92%

The decreased connectivity in middle temporal gyrus can be used as a potential neuroimaging biomarker for left temporal lobe epilepsy

Guo

et al. 2022

Front. Psychiatry

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ObjectiveWe aimed to explore voxel-mirrored homotopic connectivity (VMHC) abnormalities between the two brain hemispheres in left temporal lobe epilepsy (lTLE) patients and to determine whether these alterations could be leveraged to guide lTLE diagnosis.Materials and methodsFifty-eight lTLE patients and sixty healthy controls (HCs) matched in age, sex, and education level were recruited to receive resting state functional magnetic resonance imaging (rs-fMRI) scan. Then VHMC analyses of bilateral brain regions were conducted based on the results of these rs-fMRI scans. The resultant imaging data were further analyzed using support vector machine (SVM) methods.ResultsCompared to HCs, patients with lTLE exhibited decreased VMHC values in the bilateral middle temporal gyrus (MTG) and middle cingulum gyrus (MCG), while no brain regions in these patients exhibited increased VMHC values. SVM analyses revealed the diagnostic accuracy of reduced bilateral MTG VMHC values to be 75.42% (89/118) when differentiating between lTLE patients and HCs, with respective sensitivity and specificity values of 74.14% (43/58) and 76.67% (46/60).ConclusionPatients with lTLE exhibit abnormal VMHC values corresponding to the impairment of functional coordination between homotopic regions of the brain. These altered MTG VMHC values may also offer value as a robust neuroimaging biomarker that can guide lTLE patient diagnosis.

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Section: Discussionsupporting

confidence: 92%

The decreased connectivity in middle temporal gyrus can be used as a potential neuroimaging biomarker for left temporal lobe epilepsy

Guo

et al. 2022

Front. Psychiatry

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“…Conversely, global alterations between lTLE patients and controls were restricted in timescale to the FC fMRI -FC EEG- β relationship, which was found to be locally dominant in the DMN. This is in line with the observation of Coito et al (2015) , Zhao et al (2022) , and Lee et al (2018) showing that FC EEG of rTLE patients undergoes more widespread alterations in brain networks than those of lTLE patients.…”

Section: Discussionsupporting

confidence: 91%

Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy

Wirsich,

Iannotti,

Ridley

et al. 2024

Network Neuroscience

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Whole-brain functional connectivity networks (connectomes) have been characterized at different scales in humans using EEG and fMRI. Multimodal epileptic networks have also been investigated but the relationship between EEG and fMRI defined networks on a whole-brain scale is unclear. A unified multimodal connectome description, mapping healthy and pathological networks would close this knowledge gap. Here, we characterize the spatial correlation between the EEG and fMRI connectomes in right and left temporal lobe epilepsy (rTLE/lTLE). From two centers, we acquired resting-state concurrent EEG-fMRI of 35 healthy controls and 34 TLE patients. EEG-fMRI data was projected into the Desikan brain atlas and functional connectomes from both modalities were correlated. EEG and fMRI connectomes were moderately correlated. This correlation was increased in rTLE when compared to controls for EEG-delta/theta/alpha. Conversely multimodal correlation in lTLE was decreased in respect to controls for EEG-beta. While the alteration was global in rTLE, in lTLE it was locally linked to the Default Mode Network. The increased multimodal correlation in rTLE and decreased correlation in lTLE suggests a modality-specific lateralized differential reorganization in TLE, which needs to be considered when comparing results from different modalities. Each modality provides distinct information, highlighting the benefit of multimodal assessment in epilepsy.

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Section: Discussionsupporting

confidence: 91%

“…Conversely global alterations between lTLE patients and controls were restricted in timescale to the FC fMRI -FC EEG-β relationship which was found to be locally dominant in the Default Mode Network. This is in line with the observation of Coito et al (2015) and Zhao et al (2022) showing that FC EEG of rTLE patients undergoes more widespread alterations in brain networks than those of lTLE patients. This finding of functional alterations affecting regions remote to the epileptic focus resulting in global shift of functional networks altered by epilepsy as a function of the laterality of the epilepsy is further supported by a recent multicentric study showing that while atrophy in lTLE is more restrained to the ipsilateral side while in rTLE both ipsi and contralateral side are affected (Park et al, 2021).…”

Section: Fc Fmri -Fc Eeg Correlationsupporting

confidence: 91%

Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy

Wirsich

Iannotti

Ridley

et al. 2022

Preprint

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Whole brain, large-scale functional connectivity networks or connectomes have been characterized on different temporal and spatial scales in humans using EEG and fMRI. Whole brain epileptic networks have been investigated with both EEG and fMRI, but due to the different acquisition approaches it is unclear to what extent those results can be related. In consequence clinical research in epilepsy would profit from a unified multimodal functional connectome description as a linking framework to better map underlying brain function and pathological functional networks. In this study we aim to characterize the spatial correlation between EEG and fMRI connectivity in temporal lobe epilepsy. From two independent centers, we acquired resting-state concurrent EEG-fMRI from a total of 35 healthy controls and 34 TLE patients (18 right TLE and 16 left TLE). Data was projected into the Desikan brain atlas (mean BOLD activity for fMRI and source reconstruction for EEG). Whole brain functional connectivity from fMRI (Pearson correlation) and EEG (corrected imaginary part of the coherency) were correlated for all subjects. In healthy controls, average EEG and fMRI whole-brain connectivity was moderately correlated (r~0.3). For both imaging centers, correlation between EEG and fMRI whole brain connectivity was increased in rTLE when compared to controls for lower frequency bands (EEG-delta, theta and alpha). Conversely correlation between EEG and fMRI connectivity of lTLE patients was decreased in respect to healthy subjects (EEG-beta vs. fMRI connectivity only). While the alteration of the EEG-fMRI correlation in rTLE patients could not be related to a local effect, in lTLE patients it was locally linked to the Default Mode Network. We demonstrated, using two independent datasets, that EEG and fMRI connectivity is correlated for both healthy subjects and patients. The increased correlation of EEG and fMRI connectivity in rTLE patients vs. controls and decreased correlation in lTLE patients vs. controls suggests a differential organization of mono-lateral focal epilepsy of the same type, which needs to be considered when comparing fMRI to EEG connectivity. It also demonstrates that each modality provides distinct information, highlighting the benefit of multimodal assessment in epilepsy. The observed property of distinct topological patterns depending on the lateralization of the epilepsy could be taken into account when clinically defining the epileptic focus of patients.

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Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy

Cited by 10 publications

References 49 publications

The decreased connectivity in middle temporal gyrus can be used as a potential neuroimaging biomarker for left temporal lobe epilepsy

The decreased connectivity in middle temporal gyrus can be used as a potential neuroimaging biomarker for left temporal lobe epilepsy

Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy

Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy

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