Interim Analysis of Pandemic Coronavirus Disease 2019 (COVID-19) and the SARS-CoV-2 virus in Latin America and the Caribbean: Morbidity, Mortality and Molecular Testing Trends in the Region

Simbaña-Rivera, Katherine

doi:10.1101/2020.04.25.20079863

Cited by 28 publications

(38 citation statements)

References 19 publications

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“…Data from the region indicates that Ecuador, along with Panama, are the two most affected countries in Latin America. Ecuador ranks 23 rd worldwide in the numbers of deaths per million inhabitants 15,16 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador

Ortíz-Prado

Simbaña-Rivera

Diaz

et al. 2020

Preprint

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Background:The SARS-CoV-2 virus has spread rapidly around the globe. Nevertheless, there is limited information describing the characteristics and outcomes of COVID-19 patients in Latin America. Methods:We conducted a cross-sectional analysis of 9,468 confirmed COVID-19 cases reported in Ecuador. We calculated overall incidence, mortality, case fatality rates, disability adjusted life years, attack and crude mortality rates, as well as relative risk and relative odds of death, adjusted for age, sex and presence of comorbidities.Results: A total of 9,468 positive COVID-19 cases and 474 deaths were included in the analysis. Men accounted for 55.4% (n = 5, 247) of cases and women for 44.6% (n = 4, 221).We found the presence of comorbidities, being male and older than 65 years were important determinants of mortality. Coastal regions were most affected by COVID-19, with higher mortality rates than the highlands. Fatigue was reported in 53.2% of the patients, followed by headache (43%), dry cough (41.7%), ageusia (37.1%) and anosmia (36.1%). Conclusion:We present the first analysis of the burden of COVID-19 in Ecuador. Our findings show that men are at higher risk of dying from COVID-19 than women, and risk increases with age and the presence of comorbidities. We also found that blue-collar workers and the unemployed are at greater risk of dying. These early observations offer clinical insights for the medical community to help improve patient care and for public health officials to strengthen Ecuador's response to the outbreak.

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Section: Discussionmentioning

confidence: 99%

Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador

Ortíz-Prado

Simbaña-Rivera

Diaz

et al. 2020

Preprint

Self Cite

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“…The median time from illness onset to hospitalization at Clinique Ngaliema was 7 days (IQR:5-10). Female attended hospital earlier than male (5 days IQR: [4][5][6][7] vs 7 days [IQR: [6][7][8][9][10][11]; p = 0.003, respectively) ( Fig 1). Out of all patients admitted, 42 (26%) were transferred from non-CTC health facilities.…”

Section: Sociodemographic Characteristics and Seeking Care Behaviormentioning

confidence: 99%

Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study

et al. 2020

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Objectives To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in Kinshasa, in the Democratic Republic of Congo (DRC). Methods This retrospective study analyzed medical records including socio-demographics, past medical history, clinical manifestation, comorbidities, laboratory data, treatment and disease outcome of 160 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection. Results The median age of patients was 54 years (IQR: 38–64), and there was no significant gender difference (51% of male). The most common comorbidities were hypertension (55 [34%]), diabetes (31 [19%]) and obesity (13 [8%]). Fever (93 [58%]), cough (92 [57%]), fatigue (87 [54%]), shortness of breath (72 [45%]) and myalgia (33 [21%]) were the most common symptoms, upon admission. Patients were categorized into mild (92 [57%]), moderate (19 [12%]) and severe (49 [31%]). Severe patients were older and were more likely to have comorbidities, compared to mild ones. The majority of patients (92% [147 of 160]) patients received hydroxychloroquine or chloroquine phosphate. Regression model revealed that older age, lower SpO2, higher heart rate and elevated AST at admission were all risk factors associated with in-hospital death. The prevalence of COVID-19 and malaria co-infection was 0.63% and 70 (44%) of all patients received antimalarial treatment before hospitalization. Conclusion Our findings indicated that the epidemiological and clinical feature of COVID-19 patients in Kinshasa are broadly similar to previous reports from other settings. Older age, lower SpO2, tachycardia, and elevated AST could help to identify patients at higher risk of death at an early stage of the illness. Plasmodium spp co-infection was not common in hospitalized COVID-19 patients.

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“…La epidemia de COVID-19 fue declarada por la OMS como una emergencia de salud pública de preocupación internacional el 30 de enero de 2020. Así, pudimos contar con aproximadamente ocho semanas para poder prepararnos 6 . Ya contábamos con información asociada al tipo de pacientes y sus comorbilidades (ej.…”

Section: En Sudamérica Sabíamos Que Iba Llegar Esta Pandemia Aún Nounclassified

La criticidad de las Unidades de Intensivo. Ampliando las Unidades en tiempos de pandemia

et al. 2020

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Expanding ICU facilities in a pandemic scenario Our country is suffering the effects of the ongoing pandemic of coronavirus disease (COVID-19). Because the vulnerability of healthcare systems, especially the intensive care areas they can rapidly be overloaded. That challenge the ICUs simultaneously on multiple fronts making urgent to increase the number of beds, without lowering the standards of care. The purpose of this article is to discuss some aspects of the national situation and to provide recommendations on the organizational management of intensive care units such as isolation protocols, surge in ICU bed capacity, ensure adequate supplies, protect and train healthcare workers maintaining quality clinical management.

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Interim Analysis of Pandemic Coronavirus Disease 2019 (COVID-19) and the SARS-CoV-2 virus in Latin America and the Caribbean: Morbidity, Mortality and Molecular Testing Trends in the Region

Cited by 28 publications

References 19 publications

Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador

Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador

Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study

La criticidad de las Unidades de Intensivo. Ampliando las Unidades en tiempos de pandemia

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