Interim clinical outcomes in the collaborative initial glaucoma treatment study comparing initial treatment randomized to medications or surgery

Lichter, Paul R.; Musch, David C.; Gillespie, Brenda W.; Guire, Kenneth E.; Janz, Nancy K.; Wren, Patricia A.; Mills, M.P.H.Richard P

doi:10.1016/s0161-6420(01)00873-9

Cited by 1,090 publications

(641 citation statements)

References 28 publications

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“…The use of combination therapy frequently is necessary at any stage of the disease, 8,9 as it has been reported in the Ocular Hypertension Treatment Study 9 and in the Collaborative Initial Glaucoma Treatment Study, 10 where up to 50% and 75% of patients, respectively, required 2 or more drugs to reach their target pressure. When 2 drugs are required to control the IOP, there are a number of potential advantages in using a fixed combination rather than separate drugs, including no risk of drug washout, 11 reduced exposure to preservatives, and ultimately better patient compliance and quality of life.…”

Section: Owering Intraocular Pressure (Iop) Is Thementioning

confidence: 99%

Comparison of Travoprost and Bimatoprost plus Timolol Fixed Combinations in Open-Angle Glaucoma Patients Previously Treated with Latanoprost plus Timolol Fixed Combination

Centofanti¹,

Oddone²,

Gandolfi³

et al. 2010

American Journal of Ophthalmology

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GIANLUCA MANNI, AND LUCA ROSSETTI• PURPOSE: To compare the ocular hypotensive effect of bimatoprost plus timolol and travoprost plus timolol fixed combinations in glaucoma patients whose disease was controlled but had not reached their target intraocular pressure (IOP) with the fixed combination of latanoprost plus timolol.• DESIGN: A 2 ؋ 3-month, multicenter, prospective, randomized, double-masked, cross-over clinical trial.•

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Section: Owering Intraocular Pressure (Iop) Is Thementioning

confidence: 99%

Comparison of Travoprost and Bimatoprost plus Timolol Fixed Combinations in Open-Angle Glaucoma Patients Previously Treated with Latanoprost plus Timolol Fixed Combination

Centofanti¹,

Oddone²,

Gandolfi³

et al. 2010

American Journal of Ophthalmology

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“…[1][2][3][4] The Collaborative Initial Glaucoma Treatment study has found that although surgery lowers intraocular pressure (IOP) more than medical therapy, no significant difference is found in visual field progression over the course of 5 years. 5 Despite these trends, trabeculectomy remains a critical treatment modality in glaucoma for those patients on maximum medical therapy with field progression, uncontrolled pressure and/or progressive nerve damage. In these patients, drainage surgery must achieve a stable reduction in IOP.…”

Section: Introductionmentioning

confidence: 99%

Trabeculectomy: a training dilemma

Troutbeck

Lee

Sanfilippo

et al. 2005

Eye

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Aim/Purpose The incidence of trabeculectomy is falling due to more effective medical therapies, resulting in fewer trabeculectomy operations carried out by Ophthalmology trainees. This study audits all primary trabeculectomy procedures performed publicly at the two major teaching hospitals in Brisbane, Australia. Method A retrospective consecutive case review analysing the rates and outcomes of Ophthalmology trainee versus consultant trabeculectomies that were performed during the period May 1996-May 2002. Results In all, 290 primary trabeculectomies were undertaken during the study period. Ophthalmology trainees performed 95 (33%) of the procedures. This represents a rate of 1.6 trabeculectomy procedures per year per trainee (10 trainees train at the two hospitals per year). Rates of complications postoperatively were similar between the trainee and consultant groups. The percentage of patients achieving an IOP p15 mmHg on no medication at their last follow-up was low at 30%. Conclusions The results of this study suggests that improvement in trabeculectomy technique is required. In order to acquire skills, wetlab training on artificial or animal eyes may become mandatory within the training programmes, otherwise trabeculectomy will become the realm of subspecialists with glaucoma fellowship training.

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“…Despite the introduction in recent years of new powerful medications, trabeculectomy has usually outperformed both medical and laser treatment in this regard. 5,6 This has led to a renewed interest in the natural history of the eye after trabeculectomy and how we can modify the operation to produce the most desirable result.…”

Section: Introductionmentioning

confidence: 99%

A review of trabeculectomy in East Asian people—the influence of race

Husain

Clarke

Seah

et al. 2004

Eye

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Glaucoma is the leading cause of irreversible blindness worldwide. East Asians account for approximately half of all glaucoma sufferers. It is likely that trabeculectomy will be needed for many of these people as the intraocular pressure is to be maintained at a satisfactorily low level. The eyes of East Asian people differ in some aspects from those of other races. This review describes the natural history of the eye after trabeculectomy in East Asians.

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Interim clinical outcomes in the collaborative initial glaucoma treatment study comparing initial treatment randomized to medications or surgery

Cited by 1,090 publications

References 28 publications

Comparison of Travoprost and Bimatoprost plus Timolol Fixed Combinations in Open-Angle Glaucoma Patients Previously Treated with Latanoprost plus Timolol Fixed Combination

Comparison of Travoprost and Bimatoprost plus Timolol Fixed Combinations in Open-Angle Glaucoma Patients Previously Treated with Latanoprost plus Timolol Fixed Combination

Trabeculectomy: a training dilemma

A review of trabeculectomy in East Asian people—the influence of race

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