Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism

Viola, Antoine; Chellappa, Sarah Laxhmi; Archer, Simon N.; Pugin, Fiona; Götz, Thomas; Dijk, Derk‐Jan; Cajochen, Christian

doi:10.1016/j.neurobiolaging.2011.10.024

Cited by 56 publications

(46 citation statements)

References 40 publications

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“…genotypes, although a recent study in older people does report a phase advance in melatonin in PER3 5/5 subjects compared to PER 4/4 (Viola et al, 2011). The influence of the PER3 VNTR on CT appears to be more closely linked with mechanisms that regulate sleep timing and homeostasis.…”

Section: Genetic Basismentioning

confidence: 84%

Circadian Typology: A Comprehensive Review

Adán¹,

Archer²,

Hidalgo³

et al. 2012

Chronobiology International

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1,066

855

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The interest in the systematic study of the circadian typology (CT) is relatively recent and has developed rapidly in the two last decades. All the existing data suggest that this individual difference affects our biological and psychological functioning, not only in health, but also in disease. In the present study, we review the current literature concerning the psychometric properties and validity of CT measures as well as individual, environmental and genetic factors that influence the CT. We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol, and melatonin), and we assess the implications for CT and adjustment to shift work and jet-lag. We also review the differences between CT in terms of cognitive abilities, personality traits and the incidence of psychiatric disorders. When necessary, we have emphasized the methodological limitations that exist today and suggested some future avenues of work in order to overcome these. This is a new field of interest to professionals in many different areas (research, labor, academic, and clinical) and this review provides a state of the art discussion to allow professionals to integrate chronobiological aspects of human behavior into their daily practice.

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Section: Genetic Basismentioning

confidence: 84%

Circadian Typology: A Comprehensive Review

Adán¹,

Archer²,

Hidalgo³

et al. 2012

Chronobiology International

Self Cite

1,066

855

View full text Add to dashboard Cite

show abstract

“…At the gene level, polymorphisms and mutations in clock genes correlate with variation in sleep timing and duration [50,51,52] and sleep structure [53,54,55]. Individual differences in the timing of molecular rhythms and melatonin concentrations in blood also correlate with individual differences in sleep timing [56].…”

Section: Sleep As a Circadian Adaptive Rhythmmentioning

confidence: 99%

Modelling changes in sleep timing and duration across the lifespan: Changes in circadian rhythmicity or sleep homeostasis?

Skeldon

Derks

Dijk

2016

Sleep Medicine Reviews

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135

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Sleep changes across the lifespan, with a delay in sleep timing and a reduction in slow wave sleep seen in adolescence, followed by further reductions in slow wave sleep but a gradual drift to earlier timing during healthy ageing. The mechanisms underlying changes in sleep timing are unclear: are they primarily related to changes in circadian processes, or to a reduction in the neural activity dependent build up of homeostatic sleep pressure during wake, or both? We review existing studies of age-related changes to sleep and explore how mathematical models can explain observed changes. Model simulations show that typical changes in sleep timing and duration, from adolesence to old age, can be understood in two ways: either as a consequence of a simultaneous reduction in the amplitude of the circadian wake-propensity rhythm and the neural activity dependent build-up of homeostatic sleep pressure during wake; or as a consequence of reduced homeostatic sleep pressure alone. A reduction in the homeostatic pressure also explains greater vulnerability of sleep to disruption and reduced daytime sleep-propensity in healthy ageing. This review highlights the important role of sleep homeostasis in sleep timing. It shows that the same phenotypic response may have multiple underlying causes, and identifies aspects of sleep to target to correct delayed sleep in adolescents and advanced sleep in later life.

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“…We found a similar trend in Canada, as older adults, relative to younger ones, had significantly increased likelihood of having troubled sleep. Epidemiological studies have shown that older adults have less slow-wave sleep (deep sleep) and rapid eye movement sleep, which affects their quality of sleep compared to those in their youthful years [63,64]. This may account for the differences seen between the older and the younger generation.…”

Section: Tablementioning

confidence: 99%