Interinformant reliability of family history information on psychiatric disorders in relatives

Ptok, Ursula; Seeher, Christian; Jessen, Frank; Papassotiropoulos, Andreas; Heun, Reinhard

doi:10.1007/s004060050025

Cited by 33 publications

(23 citation statements)

References 27 publications

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“…Gershon and Guroff (1984) have indicated that the values for diagnostic agreement between a clinician's diagnosis of unipolar depression in an individual and a relative's report is 0.42, which is considered fair. Structured interviews such as the one we used can optimize the acquisition of family history information (Heun and Muller, 1998;Ptok et al, 2001). Nevertheless, the lack of direct interview data from the relatives of the subjects represents a significant limitation in a population-based study.…”

Section: Discussionmentioning

confidence: 99%

A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression

Hines¹,

Hoffman²,

Bhave³

et al. 2006

J. Neurosci.

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Major depression represents a complex mental disorder. The identification of biological markers that define subtypes of major depressive disorder would greatly facilitate appropriate medical treatments, as well as provide insight into etiology. Reduced activity of the cAMP signaling system has been implicated in the etiology of major depression. Previous work has shown low adenylyl cyclase activity in platelets and postmortem brain tissue of depressed individuals. Here, we investigate the role of the brain type VII isoform of adenylyl cyclase (AC7) in the manifestation of depressive symptoms in genetically modified animals, using a combination of in vivo behavioral experiments, gene expression profiling, and bioinformatics. We also completed studies with humans on the association of polymorphisms in the AC7 gene with major depressive illness (unipolar depression) based on Diagnostic and Statistical Manual of Mental Disorders IV criteria. Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness.

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Section: Discussionmentioning

confidence: 99%

A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression

Hines¹,

Hoffman²,

Bhave³

et al. 2006

J. Neurosci.

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“…History of psychiatric illness was not included in FABS secondary to its subjectiveness and low interinformant reliability. 17,18 We also excluded lowdensity lipoprotein and A1C because the results most likely would not be available in the emergency setting.…”

Section: Construct An Intuitive Scoring Systemmentioning

confidence: 99%

Fabs

Goyal

Tsivgoulis

Male

et al. 2016

Stroke

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Background and Purpose-A large number of patients with symptoms of acute cerebral ischemia are stroke mimics (SMs).In this study, we sought to develop a scoring system (FABS) for screening and stratifying SM from acute cerebral ischemia and to identify patients who may require magnetic resonance imaging to confirm or refute a diagnosis of stroke in the emergency setting. Methods-We designed a scoring system: FABS (6 variables with 1 point for each variable present): absence of Facial droop, negative history of Atrial fibrillation, Age <50 years, systolic Blood pressure <150 mm Hg at presentation, history of Seizures, and isolated Sensory symptoms without weakness at presentation. We evaluated consecutive patients with symptoms of acute cerebral ischemia and a negative head computed tomography for any acute finding within 4.5 hours after symptom onset in 2 tertiary care stroke centers for validation of FABS. Results-A total of 784 patients (41% SMs) were evaluated. Receiver operating characteristic curve (C statistic, 0.95; 95% confidence interval [CI], 0.93-0.98) indicated that FABS≥3 could identify patients with SM with 90% sensitivity (95% CI, 86%-93%) and 91% specificity (95% CI, 88%-93%). The negative predictive value and positive predictive value were 93% (95% CI, 90%-95%) and 87% (95% CI, 83%-91%), respectively. Conclusions-FABS seems to be reliable in stratifying SM from acute cerebral ischemia cases among patients in whom the head computed tomography was negative for any acute findings. It can help clinicians consider advanced imaging for further diagnosis.

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“…However, this was not feasible within the framework of the present study. As shown by other studies confronted with this difficulty [12,15], the diagnosis of disorders occurring in the family therefore has to be made with the greatest possible care as far as incorrect/correct is concerned.…”

Section: Gas Scorementioning

confidence: 99%

The Influence of Familial Loading on the Course of Schizophrenic Symptoms and the Success of Psychoeducational Therapy

Feldmann

Hornung²,

Buchkremer

et al. 2001

Psychopathology

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This prospective study examines the influence of familial loading on the course of schizophrenic illness and the extent to which this is modifiable by psychoeducational training as a form of psychotherapy. 182 schizophrenic patients enrolled in the study were allocated at random into four different treatment groups and one control group. 40% of the patients had mentally ill relatives, 20% with some form of schizophrenia. Patients attending the treatment group and those in the control group were examined before and immediately after psychoeducational training and at 2-year and 5-year follow-ups. Control group patients with mentally ill relatives displayed a significant increase in psychopathological symptoms and rehospitalization rate compared to those without. The psychoeducational training arrested or even improved the increase in psychopathological symptoms in patients with mentally ill relatives. Familial loading contributes substantially to a high rehospitalization rate and a poor outcome in schizophrenic patients. Psychoeducational interventions are an appropriate means of arresting this unfavorable development.

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Interinformant reliability of family history information on psychiatric disorders in relatives

Cited by 33 publications

References 27 publications

A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression

A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression

Fabs

The Influence of Familial Loading on the Course of Schizophrenic Symptoms and the Success of Psychoeducational Therapy

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