Interlaboratory Histopathologic Assessment of Alzheimer Neuropathology

Dw, McKeel; Mj, Ball; Jl, Price; Ds, Smith; Jp, Miller; Berg, Leonard van den; Jc, Morris

doi:10.1097/00002093-199307030-00003

Cited by 37 publications

(3 citation statements)

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“…Of the 30 PDD participants who came to autopsy, 21 cases had neocortical Lewy bodies (Braak stages 5–6) sufficient to meet pathological criteria for DLB; 8 cases had pure DLB while 13 cases had mixed pathology. Nine cases had subcortical Lewy bodies (Braak stages 2–3) but no limbic or cortical Lewy bodies; instead these cases had AD pathology (diffuse and neuritic plaques and neurofibrillary tangles) sufficient to meet Washington University criteria for AD [21] with most cases meeting intermediate probability by National Institute on Aging-Reagan criteria. These findings are consistent with reports that cortical Lewy body pathology accounts for most cases of PDD; however, AD pathology may explain up to a third of cases [6,11].…”

Section: Resultsmentioning

confidence: 99%

“…All brains were examined with a standard protocol [21]. Following fixation in neutral buffered 10% formalin, tissue blocks were taken from 30 brain regions.…”

Section: Methodsmentioning

confidence: 99%

“…Following fixation in neutral buffered 10% formalin, tissue blocks were taken from 30 brain regions. Sections (6 µm) from paraffin-embedded tissue blocks were stained with hematoxylin-eosin, Gallyas and modified Bielchowsky silver stains and immunohistochemical methods [21]. Histological criteria for AD were based on quantification of diffuse and neuritic amyloid deposition in five cortical regions with 10-mm [2] microscopic fields in each region using modified Khachaturian criteria [22].…”

Section: Methodsmentioning

confidence: 99%

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Longitudinal Changes in Cognition in Parkinson’s Disease with and without Dementia

Johnson

Galvin²

2011

Dement Geriatr Cogn Disord

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Background: The longitudinal cognitive course in Parkinson’s disease (PD) with and without dementia remains undefined. We compared cross-sectional models of cognition in PD (both with and without dementia), Alzheimer’s disease (AD), and nondemented aging and followed the participants over time. Method: Previously validated models of cognitive performance in AD and nondemented aging were extended to individuals with PD (with dementia, n = 71; without dementia, n = 47). Confirmatory factor analysis and piecewise regression were used to compare the longitudinal course of participants with PD with 191 cognitively healthy subjects and 115 individuals with autopsy-confirmed AD. Results: A factor analytic model with one general factor and three specific factors (verbal memory, visuospatial memory, working memory) fit demented and nondemented PD. Longitudinal change indicated that individuals with PD with dementia declined significantly more rapidly on visuospatial and verbal memory tasks than AD alone. Cognitive declines across all factors in AD and PD dementia accelerated several years prior to clinical dementia diagnosis. Conclusion: Both specific and global cognitive changes are witnessed in PD and AD. Longitudinal profiles of cognitive decline in PD and AD differed. PD with or without dementia has a core feature of longitudinal decline in visuospatial abilities.

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Section: Resultsmentioning

confidence: 99%

“…All brains were examined with a standard protocol [21]. Following fixation in neutral buffered 10% formalin, tissue blocks were taken from 30 brain regions.…”

Section: Methodsmentioning

confidence: 99%