Interlaboratory reproducibility of atypical glandular cells of undetermined significance: a national survey

Confortini, Massimo; Bonito, Luigi Di; Carozzi, Francesca; Ghiringhello, Bruno; Montanari, G; Parisio, F.; Prandi, Sonia

doi:10.1111/j.1365-2303.2006.00372.x

Cited by 23 publications

(20 citation statements)

References 21 publications

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“…Notably, the reproducibility of AGC as a cytologic category is poor. 13 The results of this analysis were similar when restricted to those women with AGC cytology unqualified. There were only minor differences in the distribution of histopathology in those women with either AGC endocervical or endometrial (combined) compared with those women with AGC unqualified (Pϭ.02), suggesting that AGC not otherwise specified is an admixture of two AGC subtypes.…”

Section: Methodssupporting

confidence: 69%

Relationship of Atypical Glandular Cell Cytology, Age, and Human Papillomavirus Detection to Cervical and Endometrial Cancer Risks

Castle

Fetterman

Poitras

et al. 2010

Obstetrics &Amp; Gynecology

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Section: Methodssupporting

confidence: 69%

Relationship of Atypical Glandular Cell Cytology, Age, and Human Papillomavirus Detection to Cervical and Endometrial Cancer Risks

Castle

Fetterman

Poitras

et al. 2010

Obstetrics &Amp; Gynecology

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“…Given the high sensitivity for CIN2+ lesions and the high reproducibility of hr-HPV testing (Carozzi et al , 2005b), its role in surveillance seems pivotal for a standardised follow-up protocol in which Pap test, whose low reproducibility rates among centres are well known (Confortini et al , 2006; Tinacci et al , 2011), should be progressively substituted. As any other test, hr-HPV testing may be affected by some false-negative results (Negri et al , 2007) and, even if only a few of those results have potential clinical significance, most of them are due to a sporadic human error in performing the test.…”

Section: Discussionmentioning

confidence: 99%

hr-HPV testing in the follow-up of women with cytological abnormalities and negative colposcopy

et al. 2013

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Background:The follow-up after abnormal Pap smear and negative colposcopy is not clearly defined. This study aimed at investigating the role of hr-HPV testing in the management of abnormal Pap test and negative colposcopy for Cervical Intraepithelial Neoplasia grade 2 or worse (CIN2+).Methods:The study enroled 1029 women with abnormal screening cytology (years 2006–2010) and negative colposcopy for CIN2+, which subsequently performed a hr-HPV test. Incident CIN2+ lesions were identified through linkage with cancer registry, hospital discharge records, neoplastic pathology reports and the archive of screening programme (2006–2011).Results:During the follow-up, the cohort developed 133 CIN2+ lesions; only one among hr-HPV-negative women. The probability of developing CIN2+ on follow-up time was 0.44% (95% confidence interval (CI) 0.1–3.1) and 41.8% (95% CI 31.8–53.5) for hr-HPV-negative women and hr-HPV-positive women, respectively. A woman with a positive hr-HPV test had about 105 times higher probability of developing a CIN2+ lesion than a woman with a negative hr-HPV test (hazard ratio (HR)=104.5, 95% CI 14.5–755.1), adjusted for index Pap test result, age and cervix squamocolumnar junction visualisation.Conclusion:Our results confirm that hr-HPV testing is able to select the real group of women at risk of developing CIN2+ lesions in the follow-up of abnormal cytology and first negative colposcopy.

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“…Cytological diagnosis of BNCs is demanding for the cytologist and is not easily reproducible (Confortini et al , 2006). Correctly categorising the cell of origin and differentiating clinically significant changes from benign counterparts may be difficult (Simsir et al , 2003).…”

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confidence: 99%

Management of borderline change in endocervical cells: a more dependable approach

et al. 2014

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Background:There are limited data and guidance from the UK on borderline nuclear change in endocervical cells (BNCs). The objective of this study is to determine the clinical outcome of women with BNCs, to determine the accuracy of colposcopy and propose a more robust management algorithm.Methods:This is a retrospective review of all BNC referrals between January 2006 and December 2011 at the Northumbria Healthcare Trust. Histological diagnosis was based on high-grade histology (CIN 2 or worse). Any high-grade histology in the first year of follow-up was included in the final diagnosis.Results:Of the 9001 new referrals, 167 women had BNCs. Thirty-seven (22%) were diagnosed with high-grade histology on initial assessment. Sixty women had satisfactory and negative colposcopy, out of which 7 (12%) were detected with high-grade histology/cytology in the first year of follow-up. Overall, 50 high-grade histology (30%), including two invasive carcinomas were detected.Conclusions:Current follow-up of BNCs relies heavily on colposcopic assessment. A significant proportion of women with negative colposcopy was found to have high-grade histology in the first year of follow-up. We propose a more robust management algorithm to lower the probability of missed high-grade histology in this subgroup of women.

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Interlaboratory reproducibility of atypical glandular cells of undetermined significance: a national survey

Cited by 23 publications

References 21 publications

Relationship of Atypical Glandular Cell Cytology, Age, and Human Papillomavirus Detection to Cervical and Endometrial Cancer Risks

Relationship of Atypical Glandular Cell Cytology, Age, and Human Papillomavirus Detection to Cervical and Endometrial Cancer Risks

hr-HPV testing in the follow-up of women with cytological abnormalities and negative colposcopy

Management of borderline change in endocervical cells: a more dependable approach

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