Interleucina-17 como Alvo Terapêutico na Psoríase

Torres, Tiago; Filipe, Paulo

doi:10.20344/amp.4777

Cited by 12 publications

(12 citation statements)

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“…However, we showed that neutrophils are high producers of IL-23 along with IL-17, CXCL8/IL-8, and CCL-20. IL-23 has a major role in generation of pathogenic Th17 cells (37, 38), which have been involved in viral hepatitis caused by HBV (39, 40), HCV (41), as well as autoimmune arthritis (42) and other chronic diseases (43). Another important observation emerging from this study was the production of CCL-20 by neutrophils, a known ligand for CCR-6 which is mainly present on Th17 cells.…”

Section: Discussionmentioning

confidence: 99%

Blockade of Neutrophil’s Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure

et al. 2017

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BackgroundNeutrophils serve as critical players in the pathogenesis of liver diseases. Chemokine receptors CXCR1 and CXCR2 are required for neutrophil chemotaxis to the site of inflammation/injury and are crucial in hepatic inflammatory response. However, key mechanism of neutrophil-mediated liver injury in acute-on-chronic liver failure (ACLF) remains highly elusive; which could be targeted for the development of new therapeutic interventions.MethodsTo demonstrate the role of CXCR1/CXCR2-expressing neutrophils in hepatic injury, we investigated CXCR1/CXCR2 receptor expression in 17 hepatitis B virus-related ACLF patients in comparison to 42 chronic hepatitis B and 18 healthy controls. Mechanism of neutrophil-mediated cell death was analyzed by in vitro coculture assays and correlated with the patient data. In addition, to find out any etiological-based variations in ACLF, 19 alcohol-related ACLF patients were also included.ResultsIn ACLF, neutrophils have high expression of CXCR1/CXCR2 receptors, which potentially participate in hepatocyte death through early apoptosis and necrosis in contact-dependent and -independent mechanisms. Importantly, blockade of CXCR1/CXCR2 with SCH 527123 antagonist significantly reduced cell death by targeting both the mechanisms. No etiology-based differences were seen between ACLF groups. Importantly, absolute neutrophil count was particularly higher in clinically severe ACLF patients and non-survivors (p < 0.0001). Multivariate analysis demonstrated ANC and CXCL8/IL-8 as a predictor of mortality. Further, receiver operating characteristics curve confirmed the cutoff of ANC >73.5% (sensitivity: 76.5% and specificity: 76.5%) and CXCL8/IL-8 >27% (sensitivity: 70% and specificity: 73%) in prediction of mortality.ConclusionBlockade of CXCR1/CXCR2 diminished the production of inflammatory mediators and reduced cell death; therefore, pharmacological neutralization of CXCR1/CXCR2 could provide novel therapeutic target in the management of ACLF.

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Section: Discussionmentioning

confidence: 99%

Blockade of Neutrophil’s Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure

et al. 2017

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“…About 15 years ago, the expression of IL-17 was detected in skin fragments of psoriatic patients, whilst it was not evidenced in normal control tissues, suggesting the involvement of IL-17 in psoriasis immunopathogenesis 30 . IL-17 is the homonymous cytokine produced by the Th17 subgroups of T-lymphocytes 4, 30…”

Section: Discussionmentioning

confidence: 99%

“…Interleukins (IL) 17 and 23 are responsible for the development and maintenance of Th17 cells, acting in production of IL-22 and IL-6, which stimulate keratinocyte proliferation. These findings regarding high levels of interleukins in the skin lesions of psoriasis patients provide tools for increasing interest about IL-23 and Th17 in psoriasis 2, 4, 5…”

Section: Introductionmentioning

confidence: 86%

Evaluation of the Th17 pathway in psoriasis and geographic tongue

Picciani

Domingos

Teixeira‐Souza

et al. 2019

Anais Brasileiros de Dermatologia

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BackgroundPsoriasis is a skin-articular disease with unclear etiopathogenesis. It has been suggested that the disease is immune-mediated by T-lymphocytes, predominantly Th17 cells. Similar to psoriasis, geographic tongue is an inflammatory disease with participation of Th17 cells and direct correlation with psoriasis.ObjectiveTo investigate and compare the inflammatory responses and the Th17 pathway in psoriasis and geographic tongue.MethodsThis was a cross-sectional study with 46 participants that were categorized into three groups: (A) patients with psoriasis vulgaris; (B) patients with geographic tongue and psoriasis; (C) patients with geographic tongue without psoriasis. All patients underwent physical examination, and a skin and oral biopsy for histopathological examination and immunohistochemical analysis with anti-IL6, anti-IL17, and anti-IL23 antibodies.ResultsHistological analysis of all lesions showed mononuclear inflammatory infiltrate. However, moderate intensity was prevalent for the patients with geographic tongue and psoriasis and geographic tongue groups. Immunopositivity for the antibodies anti-IL6, anti-IL17, and anti-IL23 revealed cytoplasmic staining, mainly basal and parabasal, in both psoriasis and geographic tongue. Regarding IL-6, in patients with geographic tongue and psoriasis cases the staining was stronger than in patients with geographic tongue without psoriasis cases. IL-17 evidenced more pronounced and extensive staining when compared to the other analyzed interleukins. IL-23 presented similar immunopositivity for both geographic tongue and psoriasis, demonstrating that the neutrophils recruited into the epithelium were stained.Study limitationThis study was limited by the number of cases.ConclusionThe inflammatory process and immunostaining of IL-6, IL-17, and IL-23 were similar in geographic tongue and psoriasis, suggesting the existence of a type of geographic tongue that represents an oral manifestation of psoriasis.

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“…Na edição de Março-Abril da Acta Médica Portuguesa os autores abordam o papel da IL-17 na imunopatogénese da psoríase e o potencial terapêutico da sua inibição 12 .…”

Section: Correspondênciaunclassified