Interleucina-18 (IL-18) y otros parámetros inmunológicos como marcadores de gravedad en la pancreatitis aguda

Martín, M. A.; Saracibar, E; Santa-Maria, Ana Raquel; Arranz, Eduardo; Garrote, J. A.; Almaraz, Ana; Olmo, M. L. del; García-Pajares, Félix; Fernández-Orcajo, P.; Velicia, R.; Blanco‐Quirós, Alfredo; Caro-Patón, A.

doi:10.4321/s1130-01082008001200006

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…On the other hand, Martin et al . compared IL-18 levels in patients suffering from AP with those in patients with cholecystolithiasis or common bile duct lithiasis without cholangitis [ 30 ]. Thirty-six patients were included in the study, in whom IL-18 levels were measured on the first, second, third, fifth, and seventh day of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…A significant difference between patients suffering from both forms of AP existed only during the first 24 h. Martin et al . assumed that IL-18 may be acknowledged as an early marker of both systemic and locoregional complications on account of its larger increase in the severe form of AP [ 30 ]. Both in patients suffering from the benign and the severe form of AP, IL-18 levels measured on the first, third, fifth, and tenth days of the disease were significantly higher than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…We noticed a slightly strengthening correlation between IL-18 and CRP levels on subsequent days of the disease in our study, which was confirmed by Wereszczynska-Siemiatkowska et al ., who presented findings concerning IL-18 serum level and its correlation with CRP in patients suffering from severe form of AP, as well as in the control group. The authors observed a correlation between IL-18 and CRP, which amounted to r = 0.41 ( p < 0.05) on the first day of hospital stay and weakened over the following days to r = 0.27 ( p < 0.05) [ 28 , 30 ]. The difference between a constant increase in the CRP and IL-18 correlation in our study as compared to the initial rise and further decrease of the strength of this phenomenon in the mentioned paper may be attributed to the difference in disease severity in both studies, with more severe patients remaining under our observation.…”

Section: Discussionmentioning

confidence: 99%

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Interleukin 18 as an early marker or prognostic factor in acute pancreatitis

Janiak

Leśniowski

Jasińska

et al. 2015

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IntroductionAcute pancreatits (AP) still reqiures better diagnostic and therapeutic options to be introduced in order to decrease its morbidity and mortality. It appears that the assessment of serum levels of interleukin 18 (IL-18) and its correlation with C-reactive protein (CRP) may provide adequate prognostic value.AimTo measure serum concentrations of IL-18 and inflammation markers such as CRP in patients with AP during subsequent hospital stay days and to assess the role of IL-18 as an early AP marker and prognostic factor.Material and methodsThirty-two patients aged 47 ±16.7 years were included into the study (17 males and 15 females), in whom AP was diagnosed based on ultrasound and computer aided tomography imaging and amylase. Serum amylase, CRP, and IL-18 levels were measured on the 1st, 2nd, 3rd, and 5th days of hospital stay. All patients were scored “B” according to Balthazar and mild AP based on Ranson criteria. The control group consisted of 30 healthy volunteers aged 50.7 ±12.4 years (15 males and 15 females).ResultsThe average IL-18 serum level in the control group was 86.91 ±4.94 pg/ml. Mean IL-18 study group levels were 128.4 ±7.6 pg/ml on the 1st, 112.0 ±4.4 pg/ml on the 3rd, and 122.8 ±6.8 pg/ml on the 5th day of AP, and were significantly higher than those in the control group, accordingly: p < 0.001, p < 0.005, p < 0.001. A positive correlation between IL-18 and CRP serum concentrations was observed. A slight increase in correlation was observed as the days went by.ConclusionsWe concluded that the serum IL-18 level increases in the initial phase of AP, and it may be used as an inflammatory reaction marker in patients with AP, and it is correlated with CRP, which may indicate its prognostic role in AP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Interleukin 18 as an early marker or prognostic factor in acute pancreatitis

Janiak

Leśniowski

Jasińska

et al. 2015

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“…Com isso, nota-se que esta interleucina pode ser preditora da severidade da PA na fase inicial. (120) Os resultados obtidos com esta pesquisa não apresentam diferença estatística entre os grupos provavelmente em decorrência do período escolhido para coleta das amostras.…”

Section: Discussionunclassified

Expressão de peptídeos antimicrobianos na mucosa intestinal de ratos idosos submetidos ao modelo de pancreatite aguda

Cunha¹

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Peptídeos antimicrobianos, também chamados na literatura médica de AMPs (Antimicrobial Peptides), são agrupamentos de 12 a 50 aminoácidos que têm funções antimicrobianas e imunorregulatórias. Os AMPs são produzidos principalmente nos epitélios, destacando-se o epitélio intestinal, onde participam da homeostase da barreira intestinal. A Pancreatite Aguda (PA) é uma doença com altas taxas de mortalidade e morbidade, na qual frequentemente ocorre translocação de bactérias e endotoxinas para o epitélio intestinal e para a corrente sanguínea. A translocação bacteriana ocorre, principalmente, devido à falência da barreira intestinal. Em idosos, a PA tende a ser uma doença mais grave, porém os mecanismos que justificam essa maior gravidade ainda não são bem compreendidos. O objetivo deste trabalho é fazer um estudo da expressão gênica dos peptídeos antimicrobianos α-defensina 5 e 7 e da catelicidina CRAMP em ratos jovens e idosos submetidos a um modelo de Pancreatite Aguda. Ratos jovens e idosos foram submetidos à PA utilizando-se Ácido Taurocólico 2,5% e, após doze horas, foram sacrificados. Foi coletado 1cm do íleo terminal para realização de RT-PCR para os genes das α-defensinas 5 e 7 e da catelicidina CRAMP. Adicionalmente, foram quantificados os níveis de mRNA das citocinas TNF-α e IL-10. Através da técnica de Milliplex, foram dosadas no soro as citocinas IFN-γ, IP-10, IL-10, IL-6, IL-18, TNF-α, IL-1β e Leptina. Como resultado, detectou-se maior expressão gênica das α-defensinas 5 e 7 no grupo de animais idosos, na vigência de insulto pancreático, quando comparado a animais jovens na mesma condição. Com relação à CRAMP, não houve diferença significativa entre os grupos. Igualmente, obteve-se expressão significativamente maior de TNF-α no íleo terminal dos ratos idosos com Pancreatite Aguda. Interessantemente, as dosagens de citocinas séricas foram semelhantes entre os grupos, demonstrando que a diferença entre a resposta inflamatória de ratos idosos e jovens é localizada. Peptídeos antimicrobianos, portanto, devem apresentar um papel central na resposta inflamatória decorrente de injúria pancreática. Palavras-chave: Peptídeos antimicrobianos. Pancreatite aguda. Citocinas próinflamatórias. Alfa-defensina5. Alfa-defensina 7.

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