Interleukin-1 alpha produced by human T-cell leukaemia virus type I-infected T cells induces intercellular adhesion molecule-1 expression on lung epithelial cells

Nakayama, Yuko; Ishikawa, Chie; Tamaki, Kazumi; Senba, Masachika; Fujita, Jiro; Mori, Nozomu

doi:10.1099/jmm.0.033456-0

Cited by 11 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study demonstrated that individuals with TSP-HAM clinical form have a high frequency of lung injury. It is possible that the mechanism of developing lesions is an in situ inflammatory process, diagnosed through bronchoalveolar lavage fluid analysis that has been shown in previous studies, which could be more evident among the TSP-HAM individuals [ 18 , 19 , 33 , 34 ], with resultant induction of lung injuries, like bronchiectasis, fibrosis and scar lesions. Fibrosis itself could induce traction bronchiectasis in a cycle of chronic lung injury.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

et al. 2021

View full text Add to dashboard Cite

Previous observational studies have demonstrated the development of pulmonary impairments in human T-lymphotropic virus type 1 (HTLV-1) infected individuals. The main observed lesions due to chronic inflammation of viral infection in situ are bronchiectasis and lung-scarring injuries. This lung inflammation may be the causal agent of restrictive and obstructive lung diseases, primarily in tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP-HAM) patients. We conducted a prospective cohort study to compare spirometry and high-resolution computed tomography (HRCT) findings among 28 HTLV-1-carrier patients over the course of 6 years (2014–2019) (male/female: 7/21; mean age: 54.7 ± 9.5, range: 41–68 years). Chest HRCT exams revealed the development and evolution of lung lesions related to TSP-HAM: including centrilobular nodules, parenchymal bands, lung cysts, bronchiectasis, ground-glass opacity, mosaic attenuation, and pleural thickening. Spirometry exams showed maintenance of respiratory function, with few alterations in parameters suggestive of obstructive and restrictive disorders primarily in individuals with lung lesions and TSP-HAM. The findings of the present study indicate that pulmonary disease related to HTLV-1 is a progressive disease, with development of new lung lesions, mainly in individuals with TSP-HAM. To improve clinical management of these individuals, we recommend that individuals diagnosed with PET-MAH undergo pulmonary evaluation.

show abstract

Section: Discussionmentioning

confidence: 99%

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[33], [34] It has been established that the Tax oncogene is an antigenic target of the adaptive immune response in HTLV-1 infected individuals. [35] Tax is also known to activate the IL-1α promoter, [36] several mouse models have demonstrated elevated levels of IL-1α in response to Tax expression, [13], [17], [37] and HTLV-1+ T cell clones produce high levels of IL-1α in culture. [38] Interestingly, Tax expression is largely restricted or absent in primary ATL cells [39], [40] and the same is true for IL-1α.…”

Section: Discussionmentioning

confidence: 99%

IL-15 Deficient Tax Mice Reveal a Role for IL-1α in Tumor Immunity

2014

View full text Add to dashboard Cite

IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15−/− TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1α and IL-1α-regulated cytokines. Moreover, anti-IL-1α antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1α targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1α as therapeutic targets in lymphoma.

show abstract

“…Specifically, HAM/TSP patients displayed lymphocytic inflammation [180][181][182] and changes in CT scan images [183][184][185]. Severe lung damage is predominantly observed in HTLV-1-associated inflammatory diseases such as HAM/TSP and uveitis due to the presence of high CD4 + CD25 + T lymphocytes, release of cytokines (i.e., IL-2, IL-12, and IFN-γ), inflammatory chemokines (i.e., MIP-1α and IP-10), and expression of ICAM-1 in the bronchioalveolar lavage fluid (BALF) [127,186]. The presence of lymphocytes in large quantities have shown to be positively correlated with high levels of FoxP3 mRNA in the BALF of patients with HTLV-1-related lung diseases [187].…”

Section: Evs In Pulmonary Diseasesmentioning

confidence: 99%

Extracellular Vesicles in HTLV-1 Communication: The Story of an Invisible Messenger

Sharif

Pinto

Mensah

et al. 2020

Viruses

View full text Add to dashboard Cite

Human T-cell lymphotropic virus type 1 (HTLV-1) infects 5–10 million people worldwide and is the causative agent of adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) as well as other inflammatory diseases. A major concern is that the most majority of individuals with HTLV-1 are asymptomatic carriers and that there is limited global attention by health care officials, setting up potential conditions for increased viral spread. HTLV-1 transmission occurs primarily through sexual intercourse, blood transfusion, intravenous drug usage, and breast feeding. Currently, there is no cure for HTLV-1 infection and only limited treatment options exist, such as class I interferons (IFN) and Zidovudine (AZT), with poor prognosis. Recently, small membrane-bound structures, known as extracellular vesicles (EVs), have received increased attention due to their potential to carry viral cargo (RNA and proteins) in multiple pathogenic infections (i.e., human immunodeficiency virus type I (HIV-1), Zika virus, and HTLV-1). In the case of HTLV-1, EVs isolated from the peripheral blood and cerebral spinal fluid (CSF) of HAM/TSP patients contained the viral transactivator protein Tax. Additionally, EVs derived from HTLV-1-infected cells (HTLV-1 EVs) promote functional effects such as cell aggregation which enhance viral spread. In this review, we present current knowledge surrounding EVs and their potential role as immune-modulating agents in cancer and other infectious diseases such as HTLV-1 and HIV-1. We discuss various features of EVs that make them prime targets for possible vehicles of future diagnostics and therapies.

show abstract

Interleukin-1 alpha produced by human T-cell leukaemia virus type I-infected T cells induces intercellular adhesion molecule-1 expression on lung epithelial cells

Abstract: The pathogenic mechanism of human T-cell leukaemia virus type I (HTLV-I)-related pulmonary disease, which involves overexpression of intercellular adhesion molecule-1 (ICAM-1) in lung epithelial cells, was investigated. The supernatant of HTLV-I-infected Tax

Cited by 11 publications

References 43 publications

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

IL-15 Deficient Tax Mice Reveal a Role for IL-1α in Tumor Immunity

Extracellular Vesicles in HTLV-1 Communication: The Story of an Invisible Messenger

Contact Info

Product

Resources

About