Interleukin-1 Beta Single-Nucleotide Polymorphism’s C Allele is Associated with Elevated Risk of Gastric Cancer in Helicobacter pylori-Infected Peruvians

Gehmert, Sebastian; Velapatiño, Billie; Herrera, Phabiola; Balqui, Jacqueline; Santivañez, Livia; Cok, Jaime; Vargas, Gloria; Combe, J; Passaro, Douglas J.; Wen, Sijin; Meyer, Frank; Berg, Douglas E.; Gilman, Robert H.

doi:10.4269/ajtmh.2009.08-0494

Cited by 17 publications

(11 citation statements)

References 42 publications

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“…Eleven studies evaluated the associations of gastric cancer risk with either IL1B-511T [39, 46, 47, 57, 67], IL1B-31C [29, 53, 54] or both [26, 30, 43]. Allele frequency of the putative risk variant (i.e., IL1B -511T or IL1B -31C) among controls ranged from 45 to 80% across studies.…”

Section: Resultsmentioning

confidence: 99%

Risk factors for gastric cancer in Latin America: a meta-analysis

Bonequi

Meneses-González

Correa

et al. 2012

Cancer Causes Control

123

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Background Latin America has among the highest gastric cancer incidence rates in the world, for reasons that are still unknown. In order to identify region-specific risk factors for gastric cancer, we conducted a meta-analysis summarizing published literature. Methods Searches of PubMed and regional databases for relevant studies published up to December 2011 yielded a total of 29 independent case-control studies. We calculated summary odds ratios (OR) for risk factors reported in at least five studies, including socioeconomic status (education), lifestyle habits (smoking and alcohol use), dietary factors (consumption of fruits, total vegetables, green vegetables, chili pepper, total meat, processed meat, red meat, fish and salt) and host genetic variants (IL1B-511T, IL1B-31C, IL1RN*2, TNFA-308A, TP53 codon 72 Arg and GSTM1 null). Study-specific ORs were extracted and summarized using random-effects models. Results Chili pepper was the only region-specific factor reported in at least five studies. Consistent with multifactorial pathogenesis, smoking, alcohol use, high consumption of red meat or processed meat, excessive salt intake and carriage of IL1RN*2 were each associated with a moderate increase in gastric cancer risk. Conversely, higher levels of education, fruit consumption, and total vegetable consumption were each associated with a moderately decreased risk. The other exposures were not significantly associated. No prospective study data were identified. Conclusion Risk factor associations for gastric cancer in Latin America are based on case-control comparisons that have uncertain reliability, particularly with regard to diet; the specific factors identified and their magnitudes of association are largely similar to those globally recognized. Future studies should emphasize prospective data collection and focus on region-specific exposures that may explain high gastric cancer risk.

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Section: Resultsmentioning

confidence: 99%

Risk factors for gastric cancer in Latin America: a meta-analysis

Bonequi

Meneses-González

Correa

et al. 2012

Cancer Causes Control

123

View full text Add to dashboard Cite

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“…In most cases the infection Helicobacter pylori is asymptomatic. H. pylori infectivity is highly dependent on ethnicity and geographical region (Gehmert et al, 2009;Martinez-Carrillo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Although the majority of infected people don't have symptoms of stomach diseases, persistent colonization and chronic inflammation increase the risk of gastritis (Gehmert et al, 2009;Martinez-Carrillo et al, 2010).…”

mentioning

confidence: 99%

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova¹,

Imanbekova²,

Logvinenko³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Importantly, there is a substantial inter-person variation in intensity of immune responses, progression of gastric pathologies, and in symptoms and clinical manifestations of carcinogenesis. Part of this variability must be due to host genetic factors [11,12], which are the focus of this article.…”

Section: Introductionmentioning

confidence: 99%