2005
DOI: 10.1016/j.cyto.2005.01.002
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Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa

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Cited by 9 publications
(9 citation statements)
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“…Studies have found both an enhancing effect on host resistance and a protective role of the IL-1 (both a and b) receptor antagonist. [25][26][27][28][29][30][31] In a murine sepsis model, a combined pretreatment regimen including IL-1 and TNFa was shown to significantly reduce mortality rates. 32,33 IL-1a, a closely related cytokine, has been found to reduce intestinal permeability and bacterial translocation in a burn and sepsis model.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Studies have found both an enhancing effect on host resistance and a protective role of the IL-1 (both a and b) receptor antagonist. [25][26][27][28][29][30][31] In a murine sepsis model, a combined pretreatment regimen including IL-1 and TNFa was shown to significantly reduce mortality rates. 32,33 IL-1a, a closely related cytokine, has been found to reduce intestinal permeability and bacterial translocation in a burn and sepsis model.…”
Section: Discussionmentioning
confidence: 99%
“…The increased IL-1b levels observed in the current study might suggest that Traumeel beneficially affects the septic process in a manner shown in prior studies. [25][26][27][28][29][30][31][32][33] …”
Section: Discussionmentioning
confidence: 99%
“…Iron depletion of macrophages could therefore mimic the effects of hypoxia, stabilizing HIF1α and promoting the transcription and synthesis of IL-1β 68 and perhaps other cytokines. IL-1β mediates systemic inflammation and activates important host defence mechanisms 69 . A direct hepcidin-mediated anti-inflammatory effect mediated by ferroportin and the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway was proposed 70 , but JAK–STAT-mediated signalling by ferroportin was not confirmed in subsequent more-detailed studies 71 .…”
Section: Iron Deficiency and Host Defencementioning
confidence: 99%
“…Of all the proinflammatory cytokines that are evoked by bacterial infections, IL‐1 is one of the most important. We have previously shown that IL‐1‐deficient mice are more susceptible than WT mice to gut‐derived sepsis arising from P. aeruginosa infection (1). In this model, bacterial translocation from the gastrointestinal tract was induced by the administration of cyclophosphamide, and the mice developed sepsis due to P. aeruginosa .…”
mentioning
confidence: 99%