Interleukin-1 gene cluster polymorphisms and risk of Alzheimer?s disease in Chinese Han population

Abstract

Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer's disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C((-)889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A ((-)889), IL-1B ((-)511) and IL-1RN variable number of tandem repeat (VNTR) polymorphisms in a sample of 145 sporadic AD patients and 181 healthy controls. Our data revealed that the three polymorphisms in IL-1 gene cluster might not play a key role in AD pathogenesis in Chinese Mainland Han population.

Genetic Analysis of Interleukin-1A C(-889)T Polymorphism with Alzheimer Disease

“…Our negative finding was consistent with that of other researchers from Chinese populations, including three from Taiwan (Kuo et al 2003;Tsai et al 2003;Wang et al 2007) and one from Mainland (Li et al 2004), However, there was still a recent study report that there was a association between IL-1A C(-889)T polymorphism and AD in Mainland Chinese population (Zhou et al 2006) and in Spanish (Infante et al 2007). The positive result obtained may be due to effect of different genetic background and/or small sample size.…”

Normal Tension Glaucoma is not Associated With the Interleukin -1α (−889) Genetic Polymorphism

“…IL-1a ( À 889) C/T polymorphism has been reported to be associated with Alzheimer disease, and the IL-1a ( À 889) T allele polymorphism has been found to increase the risk of developing Alzheimer disease in whites. [10][11][12] However, no association between the IL-1a ( À 889) T allele polymorphism and Alzheimer disease was noted in Chinese 22,23 or Korean 24 populations. The IL-1a ( À 889) T allele is rarer in Asians than in whites.…”

Interleukin-1α –889 C/T Polymorphism in Turkish Patients with Late-Onset Alzheimer’s Disease

“…The studies of interleukin-1 ␣ -889 C/T polymorphism in the English population suggest a similar distribution of the C/C genotype, but slight distribution differences in both C/T and T/T genotypes when compared with the Turkish population [11] . On the other hand, the results in Japanese [23] and Chinese [20] populations showed significant differences for all of the genotypes when compared with the Turkish, English [11] and Italian [9] populations. However, the allelic distribution of Turkish population is similar to the English [11] and Italian [9] populations, but differs significantly from Japanese [23] and Chinese [20] populations ( table 2 ).…”

“…On the other hand, the results in Japanese [23] and Chinese [20] populations showed significant differences for all of the genotypes when compared with the Turkish, English [11] and Italian [9] populations. However, the allelic distribution of Turkish population is similar to the English [11] and Italian [9] populations, but differs significantly from Japanese [23] and Chinese [20] populations ( table 2 ). These differences in the interleukin-1 ␣ genotype distributions might depend on the ethnic background.…”

“…This association was observed in patients from Italy [3,9,14] [14,18,21,22,24,25,28] and Asians [16,17,19,20,23,26,27] .…”