Interleukin-1 genotype-selective inhibition of inflammatory mediators by a botanical: a nutrigenetics proof of concept

Kornman, Kenneth S.; Rogus, John; Roh-Schmidt, Haeri; Krempin, David; Davies, Audra J.; Grann, Kerry; Randolph, R. Keith

doi:10.1016/j.nut.2007.08.005

Cited by 28 publications

(7 citation statements)

References 32 publications

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“…They were classified as IL-1 positive genotype if they had any of the following 3 genotypes: (1) homozygous for the common allele (C) at IL1B (−511); (2) carrying 2 copies of the less common allele (T) at IL1A (+4845); or (3) carrying one copy of the less common allele at IL1A (+4845) plus at least one copy of the less common allele (T) at IL1B (+3954). IL-1 positive genotype individuals receiving the formulation experienced a greater reduction in IL-1B gene expression and in plasma CRP levels [81]. …”

Section: Interleukin-1βmentioning

confidence: 99%

Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

et al. 2011

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Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described.

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Section: Interleukin-1βmentioning

confidence: 99%

Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

et al. 2011

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“…A more recent study has shown that the observed effect on osteoarthritis by rosehips might also be due to fatty acids in the seeds: alpha-linolenic and linoleic acids (J€ ager et al 2008). There are also indications that rosehip extracts together with minor amounts of blueberry, blackberry, and grapevine extracts may diminish the risk of cardiovascular diseases by lowering the levels of inflammatory substances associated with early heart infarctions (Kornman et al 2007).…”

Section: Useful Dogrosesmentioning

confidence: 99%

Rosa

Smulders

Arens

Koning-Boucoiran³

et al. 2011

Wild Crop Relatives: Genomic and Breeding Resources

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Article 25fa states that the author of a short scientific work funded either wholly or partially by Dutch public funds is entitled to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work.This publication is distributed under The Association of Universities in the Netherlands (VSNU) 'Article 25fa implementation' project. In this project research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication.

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“…Interesting and exciting preliminary results have been accomplished [122,[138][139][140], but even more studies are needed. Moreover, although in the postgenomic era, it could appear a limitation to examine few polymorphisms in about 1% of the total human genes, an individual whole genome sequence is still too expensive and difficult to analyze [141].…”

Section: Genetic Testing In Modern Nutrition: Is It Worth It?mentioning

confidence: 99%

Nutritional genomics era: opportunities toward a genome-tailored nutritional regimen

Costa

Casamassimi

Ciccodicola

2010

The Journal of Nutritional Biochemistry

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Interleukin-1 genotype-selective inhibition of inflammatory mediators by a botanical: a nutrigenetics proof of concept

Cited by 28 publications

References 32 publications

Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Rosa

Nutritional genomics era: opportunities toward a genome-tailored nutritional regimen

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