“…Interestingly, C/C genotype of IL1‐β −511 T>C polymorphism, was associated with risk of developing diabetes and glucose homeostasis in Finnish population Luotola et al with risk of silent myocardial infarction in diabetic patients, Vargas‐Alarcón et al with ulcerative colitis in Mexican population Yamamoto‐Furusho et al with risk of coronary artery disease Rechciński et al and with a higher susceptibility to febrile seizures in Egyptian children Abdel Rasol et al…”
C allele of IL-1 β -511 T >C could be considered risk factor contributor to T2DM and excess level of IL-1 β transcript may disclose to some degree the inflammatory role of cytokines in T2DM.
“…Interestingly, C/C genotype of IL1‐β −511 T>C polymorphism, was associated with risk of developing diabetes and glucose homeostasis in Finnish population Luotola et al with risk of silent myocardial infarction in diabetic patients, Vargas‐Alarcón et al with ulcerative colitis in Mexican population Yamamoto‐Furusho et al with risk of coronary artery disease Rechciński et al and with a higher susceptibility to febrile seizures in Egyptian children Abdel Rasol et al…”
C allele of IL-1 β -511 T >C could be considered risk factor contributor to T2DM and excess level of IL-1 β transcript may disclose to some degree the inflammatory role of cytokines in T2DM.
Certain alleles, genotypes, and haplotypes in TGFB genes were over represented in patients with FS, which possibly could predispose individuals to this disease.
The results of this meta-analysis suggest that CSF IL-1β level and serum IL-6 level are associated with an increased risk of FSs in children. Based on these results, it is expected that a therapeutic agent for specific cytokines could be developed in the future to prevent FS.
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