Interleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardation

Kayar, Nezahat Arzu; Alptekin, Nilgün Özlem; Haliloğlu, Seyfullah

doi:10.4103/1305-7456.149655

Cited by 7 publications

(7 citation statements)

References 48 publications

(76 reference statements)

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“…Os coeficientes Kappa interexaminadores foram de 1 (para a fase de leitura de títulos e resumos) e 0,90 (para a fase de leitura do texto na íntegra). Entre os 15 artigos utilizados no levantamento bibliográfico, três eram estudos transversais [4,18,27], oito caso controle [13,16,21,24,26,30,37,42], dois de coorte prospectivos [5,45] e dois ensaios clínicos randomizados [6,34]. Os estudos foram conduzidos em nove países: África do Sul, Brasil, Colômbia, Espanha, Hungria, Itália, Irã, Tanzânia e Turquia.…”

Section: Resultsunclassified

“…A presente revisão integrativa investigou a possível associação entre DP e desfechos adversos da gestação. Com base nessa revisão, a maioria dos estudos mostrou associação entre indicadores clínicos de DP e desfechos adversos gestacionais, tais como PP e BPN [4,5,13,18,21,22,24,26,28,34,37,45]. Também houve a não associação específica relatada em outros estudos [6,16,27,30,42].…”

Section: Discussionunclassified

“…Ao se considerar a literatura selecionada, um dos fatores potenciais mais desafiadores foi a heterogeneidade nas definições de periodontite. Alguns dos estudos empregaram as medidas clínicas comumente usadas da DP (perda de inserção clínica e PS) [5,6,13,16,21,27,26,30,37,42,45]. Outros basearam-se no IPC [4,18,24].…”

Section: Discussionunclassified

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Relação entre doença periodontal, prematuridade e baixo peso ao nascer: uma revisão integrativa da literatura

Vieira¹,

Magalhães²,

Chaves³

et al. 2021

RSBO

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Revisar a literatura sobre a associação da doença periodontal com prematuridade e com baixo peso ao nascer. Material e métodos: No banco de dados PubMed e Google Scholar, utilizando a seguinte combinação de palavras: “Periodontal Diseases” [Majr] AND (Prematurity OR Low Birth Weight), foi realizada uma revisão integrativa da literatura envolvendo estudos humanos publicados no período de 2015 a 2020, avaliando a associação entre doença periodontal e prematuridade/baixo peso ao nascer. Resultados: A busca eletrônica resultou num total de 352 referências, reduzidas aos critérios de estudos humanos a 343, ao período a 53 e à leitura de títulos e resumos a 16. Após leitura da íntegra dos 16 artigos, foram selecionados 15 para o presente estudo, entre os quais três são estudos transversais, oito caso controle, dois estudos de coorte prospectivos e dois ensaios clínicos randomizados com resultados divergentes para tal associação. Conclusão: A maioria dos estudos analisados considera a relação da doença periodontal com parto prematuro e baixo peso ao nascer. Há necessidade de medidas preventivas, padronização de métodos e pesquisas específicas para evitar os efeitos adversos gestacionais.

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Section: Resultsunclassified

Section: Discussionunclassified

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Relação entre doença periodontal, prematuridade e baixo peso ao nascer: uma revisão integrativa da literatura

Vieira¹,

Magalhães²,

Chaves³

et al. 2021

RSBO

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“…For example, polymorphism in IL-1 and levels of IL-1, IL-8, and IL-17 in gingival crevicular fluid have been shown to be associated with severity of the periodontal condition. [ 25 26 27 ]…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphism at −1087 locus of interleukin-10 gene promoter is associated with severe chronic periodontitis in nonsmoking patients

et al. 2015

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Objective:Single nucleotide polymorphisms (SNPs) in the promoter region of interleukin (IL)-10 gene, which codes for the anti-inflammatory cytokine IL-10, have been associated with its level of production in chronic periodontitis. The prevalence of promoter SNP genotypes is known in other populations with chronic periodontitis, while its association in the Indian population is not known. Hence, the present study was designed to investigate the prevalence of IL-10 promoter polymorphism in a racially defined group of Indians with severe chronic periodontitis as the Indian population is known to be genetically diverse.Materials and Methods:Genomic deoxyribonucleic acid was extracted from 46 nonsmoking patients with severe chronic periodontitis and 45 subjects with healthy periodontium. A SNP locus at −1087 of IL-10 was chosen, as this locus has been frequently associated with chronic periodontitis in other population. Genotyping was carried out using allele-specific polymerase chain reaction (AS-PCR), and the frequencies of genotype were analyzed between the groups.Results:The distribution of genotype and allele frequencies showed significant differences between the study groups. The prevalence of genotype AA alleles at −1087 locus of IL-10 was significantly higher in severe chronic periodontitis patients compared to the healthy controls (P = 0.05).Conclusion:The study has identified a positive association between the occurrence of AA allele at −1087 locus of IL-10 gene and severe chronic periodontitis in nonsmoking patients.

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“…The apoptotic pathways have at the basis of the process the activation of caspases, that degrade cellular components in order to be recognized by phagocytes [ 7 , 8 ]. Caspases are part of a family of cysteine proteases preserved throughout evolution and involved in cell death, as well as in the inflammatory response [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Bcl-xL: A Focus on Melanoma Pathobiology

Luciano

Pérez-Oliva

Mulero

et al. 2021

IJMS

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Apoptosis is the main mechanism by which multicellular organisms eliminate damaged or unwanted cells. To regulate this process, a balance between pro-survival and pro-apoptotic proteins is necessary in order to avoid impaired apoptosis, which is the cause of several pathologies, including cancer. Among the anti-apoptotic proteins, Bcl-xL exhibits a high conformational flexibility, whose regulation is strictly controlled by alternative splicing and post-transcriptional regulation mediated by transcription factors or microRNAs. It shows relevant functions in different forms of cancer, including melanoma. In melanoma, Bcl-xL contributes to both canonical roles, such as pro-survival, protection from apoptosis and induction of drug resistance, and non-canonical functions, including promotion of cell migration and invasion, and angiogenesis. Growing evidence indicates that Bcl-xL inhibition can be helpful for cancer patients, but at present, effective and safe therapies targeting Bcl-xL are lacking due to toxicity to platelets. In this review, we summarized findings describing the mechanisms of Bcl-xL regulation, and the role that Bcl-xL plays in melanoma pathobiology and response to therapy. From these findings, it emerged that even if Bcl-xL plays a crucial role in melanoma pathobiology, we need further studies aimed at evaluating the involvement of Bcl-xL and other members of the Bcl-2 family in the progression of melanoma and at identifying new non-toxic Bcl-xL inhibitors.

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Interleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardation

Cited by 7 publications

References 48 publications

Relação entre doença periodontal, prematuridade e baixo peso ao nascer: uma revisão integrativa da literatura

Relação entre doença periodontal, prematuridade e baixo peso ao nascer: uma revisão integrativa da literatura

Single nucleotide polymorphism at −1087 locus of interleukin-10 gene promoter is associated with severe chronic periodontitis in nonsmoking patients

Bcl-xL: A Focus on Melanoma Pathobiology

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