Interleukin-1 Receptor Antagonist (<em>IL1RA</em>) and Interleukin-4 (<em>IL4</em>) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects
Abstract:IL1RA intron 2 86-bp repeat and IL4 intron 3 70-bp repeat are VNTRs that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association of IL1RA and IL4 VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions of IL1RA and IL4 were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. … Show more
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