1986
DOI: 10.1055/s-0038-1661661
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Interleukin 1 Stimulates Endothelial Cell Tissue Factor Production and Expression by a Prostaglandin-Independent Mechanism

Abstract: SummaryActivation of coagulation occurs at inflammatory sites following the ingress of mononuclear cells, and may result from alterations in the vessel wall. Since the monokine, interleukin 1, initiates diverse responses to inflammation, its ability to enhance vascular procoagulant activity was studied. Interleukin 1-treated cultured human endothelial cells acquired elevated levels of the procoagulant, tissue factor. This required de novo protein synthesis, was maximal at 2 h after exposure to interleukin 1, a… Show more

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Cited by 58 publications
(28 citation statements)
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“…Escherichia coli is the most frequent causative agent in septic shock (2), the symptoms of which are primarily due to lipopolysaccharide (LPS). After a 4-hr incubation, LPS stimulates the generation of prostacyclin (PGI2) from endothelial cells (3)(4)(5), which may contribute to the vasodilation (through a cAMP-mediated relaxation of vascular smooth muscle) and decreased arterial blood pressure in shock (6,7).…”
mentioning
confidence: 99%
“…Escherichia coli is the most frequent causative agent in septic shock (2), the symptoms of which are primarily due to lipopolysaccharide (LPS). After a 4-hr incubation, LPS stimulates the generation of prostacyclin (PGI2) from endothelial cells (3)(4)(5), which may contribute to the vasodilation (through a cAMP-mediated relaxation of vascular smooth muscle) and decreased arterial blood pressure in shock (6,7).…”
mentioning
confidence: 99%
“…The effect of protracted exposure of endothelial cells to high glucose was also studied with respect to the procoagulant activity induced by IL-1 (29,32). In contrast with their greater tissue-factor production in response to thrombin, cultures exposed to 30 mM glucose responded to IL-1 stimulation with significantly less total tissue-factor production (cell lysates) than control cultures (P = .045; Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The concentration of a-thrombin (2.5 U/ml) matched the levels generated during blood clotting (28) and was chosen after observing that concentrations between 1 and 20 U/ml induced maximal tissue-factor production. The concentration of IL-1 (5 U/ml) was chosen on the basis of reported dose responses (29).…”
mentioning
confidence: 99%
“…These cytokines cause endothelial cell damage and downregulate the expression of TM in parallel with upregulation of TF and plasminogen activator inhibitor-1 (PAI-1) on the cell surface of endothelial cells, resulting in hypercoagulability [53,54] (Fig. 1).…”
Section: Hypercoagulabilitymentioning
confidence: 99%