Interleukin-10 concentration and coronary heart disease (CHD) event risk in the estrogen replacement and atherosclerosis (ERA) study

Abstract

Interleukin-10 (IL-10) is a cytokine with pleiotropic properties. Limited biochemical and clinical evidence suggest a link between IL-10 and coronary heart disease (CHD). However, more data are needed to clarify the relationship between IL-10 and risk for CHD events.METHODS-The present study was a secondary analysis of the Estrogen Replacement and Atherosclerosis (ERA) trial, a randomized clinical trial that examined the effects of hormone replacement therapy on post-menopausal women with known coronary atherosclerosis. IL-10 concentration, measured at baseline, was treated as both a continuous and categorical variable. Cox proportional hazards models were used to compute hazard ratios as estimates of relative risk for CHD events.RESULTS-There were 71 events over an average 3.2 year follow-up. Incident rates were higher for individuals with IL-10 concentrations equal to or greater than the median level (1.04 pg/mL) compared to those individuals below the median level (30% vs. 18.5 %, p=0.02). The cumulative incidence of CHD events was significantly greater in individuals with IL-10 concentrations ≥1.04 pg/mL (p=0.01). A one standard deviation increase in baseline IL-10 concentration was associated with a 34% greater risk of a CHD event (HR 1.34 [1.06−1.68], p=0.01). This elevated risk was not altered by interleukin-6, C-reactive protein, or additional cardiovascular risk factors. IL-10 concentration and risk for CHD events was most pronounced in diabetics , p=0.0005).CONCLUSION-In the ERA trial, elevated IL-10 concentration was associated with an increased risk for future cardiovascular events in post-menopausal women with established coronary atherosclerosis. Further study of the relationship between IL-10 and the pathogenesis and progression of atherosclerosis and cardiovascular events is warranted.

The anti‐inflammatory effect of baicalin on hypoxia/reoxygenation and TNF‐α induced injury in cultural rat cardiomyocytes

“…The effect of IL-10 administration has been studied in various models of I/R injury. In most of these studies, IL-10 appears to have an anti-inflammatory effect and attenuates the organ damage caused by I/R (Lakoski et al, 2008). In this study, we used primary culture of neonatal rat cardiomyocytes to investigate the effect of baicalin on cell injury induced by hypoxia/reoxygenation or by TNF-α.…”

A putative association of interleukin‐10 promoter polymorphisms with cardiovascular disease

“…UA and NSTEMI has showed conflicting results related with the modulation in IL-10 level (26)(27)(28). Moreover, an increase in IL-10 expression and CD4 1 and CD8 1 T-cells has been reported in unstable plaque and acute coronary syndrome (29,30). We also observed a significant increase in IL-10 level in all categorized CVD patients ( Table 2).…”

Polyphenols from Red Wine Modulate Immune Responsiveness: Biological and Clinical Significance

“…IL-10 seems to control the proinflammatory pathway even if limited biochemical and clinical evidence suggests a link between IL-10 and CHD [168]. In fact, in a randomized clinical trial, that examined the effects of hormone replacement therapy on post-menopausal women with known coronary atherosclerosis, elevated IL-10 concentration was associated with an increased risk for future cardiovascular events.…”