Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.

Brière, Francine; Bridon, Jean-Michel; Chevet, D; Souillet, G; Bienvenu, F.; Guret, Christiane; Martinez‐Valdez, Héctor; Banchereau, Jacques

doi:10.1172/jci117354

Cited by 129 publications

(78 citation statements)

References 33 publications

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“…Patients with IgA deficiency are usually defined by serum IgA levels of Ͻ0.05 g/liter (normal levels are 0.5 to 3.5 g/liter), but many, if not most, IgA-deficient patients have low but detectable levels of serum IgA antibodies (9,30) and can produce IgA antibodies at near-normal levels in vitro (8,23). This is in contrast to the complete lack of IgA production in IgA-deficient mice, which lack crucial gene segments for expressing IgA heavy chains (17).…”

Section: Discussionmentioning

confidence: 99%

Central Importance of Immunoglobulin A in Host Defense againstGiardiaspp

Housley²,

et al. 2002

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The protozoan pathogen Giardia is an important cause of parasitic diarrheal disease worldwide. It colonizes the lumen of the small intestine, suggesting that effective host defenses must act luminally. Immunoglobulin A (IgA) antibodies are presumed to be important for controlling Giardia infection, but direct evidence for this function is lacking. B-cell-independent effector mechanisms also exist and may be equally important for antigiardial host defense. To determine the importance of the immunoglobulin isotypes that are transported into the intestinal lumen, IgA and IgM, for antigiardial host defense, we infected gene-targeted mice lacking IgA-expressing B-cells, IgM-secreting B-cells, or all B-cells as controls with Giardia muris or Giardia lamblia GS/M-83-H7. We found that IgA-deficient mice could not eradicate either G. muris or G. lamblia infection, demonstrating that IgA is required for their clearance. Furthermore, although neither B-cell-deficient nor IgA-deficient mice could clear G. muris infections, IgA-deficient mice controlled infection significantly better than B-cell-deficient mice, suggesting the existence of B-cell-dependent but IgA-independent antigiardial defenses. In contrast, mice deficient for secreted IgM antibodies cleared G. muris infection normally, indicating that they have no unique functions in antigiardial host defense. These data, together with the finding that B-cell-deficient mice have some, albeit limited, residual capacity to control G. muris infection, show that IgA-dependent host defenses are central for eradicating Giardia spp. Moreover, B-cell-dependent but IgAindependent and B-cell-independent antigiardial host defenses exist but are less important for controlling infection.

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Section: Discussionmentioning

confidence: 99%

Central Importance of Immunoglobulin A in Host Defense againstGiardiaspp

Housley²,

et al. 2002

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“…Subjects with asthma that respond with a Th2-dominant response may therefore be less able to clear the organism, possibly leading to persistence of the organism. It has been shown that production of IL-10 by Th2 leads to increased B-cell production of IgA [25], suggesting that elevated IgA levels or an increase in levels of IgA directed against C. pneumoniae may be an important marker of subjects who are less able to clear C. pneumoniae [25]. The present results are in keeping with this, as the majority of responders to C. pneumoniae demonstrated an increase in IgA levels, and this was associated with an increase in sputum neutrophil count at presentation with acute asthma.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia pneumoniaeimmunoglobulin A reactivation and airway inflammation in acute asthma

Wark

Johnston²,

Simpson³

et al. 2002

Eur Respir J

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Infection with Chlamydia pneumoniae can trigger acute asthma and is associated with severe chronic asthma. The aim of the present study was to examine the relationship between airway inflammation and serological response to C. pneumoniae in acute severe asthma.Subjects (n=54) were recruited within 4 h of presentation to the emergency department with an acute exacerbation of asthma. Clinical history taking, sputum induction (0.9% saline), spirometry and acute and convalescent serology for C. pneumoniae immunoglobulins A and G were performed.At presentation, 47% of subjects had antibodies directed against C. pneumoniae, and 38% (20) demonstrated an increase in C. pneumoniae antibody levels, with 15 demonstrating a rise in immunoglobulin A concentration. C. pneumoniae responders exhibited significantly higher sputum neutrophil levels (4.6610 6 cells?mL -1 ) compared to nonresponders (1.2610 6 cells?mL -1 , p=0.02) and elevated sputum eosinophil cationic protein concentration (3,981 versus 1,122 ng?mL -1 , p=0.02). An acute antibody response to Chlamydia pneumoniae is common in exacerbations of asthma. The serological features suggest that Chlamydia pneumoniae reactivation may trigger neutrophilic airway inflammation in acute asthma. Eur Respir J 2002; 20: 834-840.

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“…Elevated specific IgA antibody levels and depressed antigen-specific cellular function in currently or formerly smoking male twins as compared to their non-smoking co-twins, suggest a predominance of the Th2 immune type response in these men. As the secretion of IgA antibodies by human B cells has been shown to be induced by IL-10, a typical product of Th2 cells [30], and as smoking is known to favour the Th2-type response among smokers [lo, 141, it is possible that the biased cytokine balance in many male smokers increases the susceptibility of these men to persistent infection.…”

Section: Discussionmentioning

confidence: 99%

Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking

Hertzen

Surcel

Kaprio

et al. 1998

Journal of Medical Microbiology

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This study investigated whether gender or smoking has an impact on immune responses to Chlumydiapneumoniue in generally healthy adults. A total of 129 twins (46 twin pairs and 37 single twins) from the Finnish %in Cohort who had previously reported the highest discordance for smoking with their co-twins participated. C. pneumoniue-specific serum IgA and IgG antibody levels were measured by the micro-immunofluorescence test (micro-IF) at admission and 3 months later if the IgA level in the first sample was elevated. Cell-mediated immune (CMI) responses to C. pneumoniae and control antigens from heparinised blood samples were assessed by the lymphoproliferation (LP) assay. When all the subjects were pooled and analysed by gender and smoking status, marked differences in the humoral immune response between the genders were observed, irrespective of smoking status. When twin pairs solely were analysed, significantly elevated IgA antibody levels suggestive of persistent infection were found among the currently or formerly smoking men compared to their non-smoking co-twins. The CMI response showed a reciprocal trend with respect to humoral immunity. In conclusion, specific antibody levels were found to be higher in men than in women irrespective of smoking status, although smoking may further enhance the humoral response and depress the CMI response in men.

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Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.

Cited by 129 publications

References 33 publications

Central Importance of Immunoglobulin A in Host Defense againstGiardiaspp

Central Importance of Immunoglobulin A in Host Defense againstGiardiaspp

Chlamydia pneumoniaeimmunoglobulin A reactivation and airway inflammation in acute asthma

Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking

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