Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

Rousset, F; Garcia, Erik Fernandez y; Defrance, Thierry; Péronne, Catherine; Vezzio, Nadia; Hsu, Di-Hwei; Kastelein, Rob; Moore, Kevin W.; Banchereau, Jacques

doi:10.1073/pnas.89.5.1890

Cited by 1,114 publications

(762 citation statements)

References 24 publications

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“…Viral IL-10 is a known growth factor for B cells and has been shown to increase antibody production in vivo. 17 Thus, it is unclear why vIL-10 gene transfer resulted in inhibition of alloantibody production. Possibly other biologic effects of vIL-10, such as blocking accessory cell function by down-regulating MHC class II expression and decreasing expression of the costimulatory molecule B7, impair effective antigen presentation and T cell helper function.…”

Section: Figure 4 Prolonged Survival Of Vil-10 Transduced Allografts mentioning

confidence: 99%

“…However, in addition to regulating immune responses negatively, IL-10 also has growth factor activity and promotes the proliferation and differentiation of B cells, mast cells and thymocytes. [16][17][18] A homologue of IL-10 encoded in the Epstein-Barr BCRF I open reading frame, designated viral IL-10, has activity on both human and mouse cells. 19 Viral IL-10 shares many of the biologic activities of cellular IL-10, including inhibition of cytokine synthesis and accessory cell function.…”

Section: Introductionmentioning

confidence: 99%

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Lipid-mediated gene transfer of viral IL-10 prolongs vascularized cardiac allograft survival by inhibiting donor-specific cellular and humoral immune responses

DeBruyne

Chan

et al. 1998

Gene Ther

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Section: Figure 4 Prolonged Survival Of Vil-10 Transduced Allografts mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipid-mediated gene transfer of viral IL-10 prolongs vascularized cardiac allograft survival by inhibiting donor-specific cellular and humoral immune responses

DeBruyne

Chan

et al. 1998

Gene Ther

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“…3 Contrary to its inhibitory function in T cells and macrophages, in B cells IL-10 stimulates the production of immunoglobulins and the expression of MHC class II antigens. 4 IL-10 has a central role in the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE) 5 and influences susceptibility and the course of various infectious diseases. [6][7][8] The constitutive expression of IL-10 in monocytes and lymphocytes is low.…”

Section: Introductionmentioning

confidence: 99%

Differential regulation of interleukin-10 production by genetic and environmental factors – a twin study

et al. 2002

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Interleukin-10 (IL-10) has a critical role in the regulation of immune responses. The relative contribution of genetic and environmental factors to IL-10 production is under debate. We performed a twin study in 246 monozygotic and dizygotic twins to assess the heritability of IL-10 production after LPS stimulation in whole blood. In addition, the influence of promoter single nucleotide polymorphisms (À1082, À819 and À592) on transcriptional activity and their binding to nuclear factors was studied in luciferase reporter gene and electrophoretic mobility shift assays. IL-10 production showed a genetic determination with a heritability of 0.5. Decreasing body mass index (BMI), smoking and female gender lead to decreased IL-10 production. In monocytes, the À1082A allele showed higher binding affinity to the transcription factor PU.1 resulting in decreased transcriptional activity of À1082A promoter haplotypes. Genetic determination of IL-10 secretion is probably lower than that previously reported. Fifty percent of the observed variability explained by genetic factors. Female individuals produce less IL-10 than male subjects. Environmental factors like smoking and decreasing BMI exert suppressing effects on IL-10 production. Although the À1082A allele shows higher binding affinity to the PU.1 transcription factor and lower transcriptional activity, this polymorphism probably explains only a small fraction of the observed heritability.

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“…1,4 Contrary to its T cell and macrophage inhibitory actions, IL10 has potent stimulatory effect on B lymphocytes, leading to their proliferation and differentiation. 5 SLE is a multisystem disease characterised by impaired T cell responses and dysregulation of B cell activation leading to B cell hyperactivity and production of autoantibodies. 6,7 Therefore, IL10 production may contribute to the disease by direct effect on B cell survival and on autoantibody production.…”

Section: Introductionmentioning

confidence: 99%

Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region

et al. 2002

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Many lines of evidence suggest that IL10 is a strong candidate gene for systemic lupus erythematosus (SLE) susceptibility. In our previously reported study an allele (IL10.G-140bp) of the microsatellite IL10.G located at position À1100 was significantly increased in Italian SLE patients in comparison with controls. Starting from this observation, we tested if sequence variations in the vicinity of IL10.G were more strongly associated with SLE. We performed a comprehensive association study including 26 SNPs (of which four were newly identified in the present study by DHPLC analysis) spanning 8.5 Kb of the 5 0 flanking and the transcribed region of the IL10 gene. The association study was performed by the DNA pool method on an extended panel of Italian patients (205) and controls (631). Haplotypic associations were studied by individual typing of seven selected markers surrounding IL10.G. Gene, genotype and haplotype frequencies were not significantly different in patients and controls. Thus the IL10.G microsatellite remains to date the only IL10 marker associated with SLE in our population. A meta-analysis of all published results indicates a possible direct role of the IL10.G repeat number in SLE susceptibiliy.

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Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

Abstract: Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by THI cells, is highly homologous to BCRF1

Cited by 1,114 publications

References 24 publications

Lipid-mediated gene transfer of viral IL-10 prolongs vascularized cardiac allograft survival by inhibiting donor-specific cellular and humoral immune responses

Lipid-mediated gene transfer of viral IL-10 prolongs vascularized cardiac allograft survival by inhibiting donor-specific cellular and humoral immune responses

Differential regulation of interleukin-10 production by genetic and environmental factors – a twin study

Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region

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