1994
DOI: 10.1128/iai.62.11.4697-4708.1994
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Interleukin-10 is expressed by bovine type 1 helper, type 2 helper, and unrestricted parasite-specific T-cell clones and inhibits proliferation of all three subsets in an accessory-cell-dependent manner

Abstract: Murine interleukin-10 (IL-10) is produced by type 2 helper (Th2) cells and selectively inhibits cytokine synthesis by type 1 helper (Thl) cells, whereas human IL-10 is produced by and inhibits proliferation and cytokine synthesis by both Thl and Th2 subsets. This study reports that bovine IL-10 mRNA is expressed by ThO, Thl, and Th2 clones of bovine T cells specific for either Babesia bovis or Fasciola hepatica but not by two CD8+ T-cell clones. The antigen-induced proliferative responses of all three subsets … Show more

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Cited by 86 publications
(31 citation statements)
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“…A more significant observation of the study was the consistent expression of IL10 by T. parva-infected cell lines, regardless of their lineage of origin. The results of a recent study suggest that, under normal circumstances, expression of IL10 by bovine lymphocytes is confined to CD4 þ T cells, for a brief period after their activation (Brown et al 1994). Our observation of consistent expression of this cytokine by T. parva-infected lymphocyte lines of all lineages therefore implies that its expression is substantially upregulated as a consequence of infection.…”
Section: Discussionsupporting
confidence: 61%
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“…A more significant observation of the study was the consistent expression of IL10 by T. parva-infected cell lines, regardless of their lineage of origin. The results of a recent study suggest that, under normal circumstances, expression of IL10 by bovine lymphocytes is confined to CD4 þ T cells, for a brief period after their activation (Brown et al 1994). Our observation of consistent expression of this cytokine by T. parva-infected lymphocyte lines of all lineages therefore implies that its expression is substantially upregulated as a consequence of infection.…”
Section: Discussionsupporting
confidence: 61%
“…In contrast, it is not possible to detect parasitespecific CTL responses in naive cattle undergoing lethal challenge with T. parva, either by direct analysis or by in vitro restimulation . Given the reported capacity of human IL10 to dampen bovine CD4 þ T cell responses (Brown et al 1994), it is tempting to speculate that the expression of this cytokine by T. parva-infected lymphocytes is associated with the pathogenesis of East Coast fever in naive animals. Since human IL10 was also observed to inhibit the proliferation of a bovine CD8 þ T cell clone (Brown et al 1994), the induction of parasite-specific CTL in naive animals could be inhibited at two levels by IL10 derived from parasitized cells.…”
Section: Discussionmentioning
confidence: 99%
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“…Several observations support the hypothesis that IFN-␥ produced by effector Th cells plays a key role in protection against babesiosis (10). In cattle, IFN-␥ regulates B-cell synthesis of the opsonizing immunoglobulin G2 subclass (17).…”
mentioning
confidence: 54%
“…Bovine γδ T cells demonstrate cytolytic activity and express IL-2, IL-4, IL-10 and IFN-γ (Brown et al 1994;Collins et al 1996). Since weak cytotoxic activity and low adhesion molecule mRNA of the cord bloodderived γδ T cell clones were observed, neonatal γδ T cells are functionally different from the majority of adult γδ T cells (Morita et al 1994).…”
Section: Discussionmentioning
confidence: 99%