Interleukin-10 polymorphisms in Spanish type 1 diabetes patients

Study of interleukin-10 promoter region polymorphisms (−1082A/G, −819T/C and −592A/C) in type 1 diabetes mellitus in Turkish population

“…The genotype frequency of IL-10 polymorphisms has been found to be different in Caucasians and Asians (D'Alfonso et al 2000;Mok et al 1998). The distribution of alleles for these SNPs in Spanish population was, however, similar to other Caucasians (Urcelay et al 2004).…”

“…Tegoshi et al (2002) did not observe a significant difference in IL-10 −592 genotype and allele frequencies between control subjects and T1DM patients in the Japanese population. Studies conducted in France and Spain did not confirm any significant association of T1DM with different haplotypes or genotypes of IL-10 promoter polymorphisms in Caucasians (Urcelay et al 2004;Reynier et al 2006). A genetic association between these three SNPs in the IL-10 promoter region and T1DM has been reported in Japanese populations, showing that −819 and −592 polymorphisms were associated with age at onset of disease (Ide et al 2002).…”

“…Interindividual differences in cytokine production appear to be related to allelic polymorphisms of cytokine genes (D'Alfonso et al 2000). IL-10 promoter SNP genotype and haplotype frequencies appear to exhibit different distributions according to ethnicity (Moraes et al 2003;Pyo et al 2003;Urcelay et al 2004). The genotype frequency of IL-10 polymorphisms has been found to be different in Caucasians and Asians (D'Alfonso et al 2000;Mok et al 1998).…”

Lack of Association of IL-10 Promoter Gene Variants with Type 1 Diabetes in a French Population

“…Also, 75% of the variation in IL-10 production appears to be genetically determined [19]. In fact, in a case-control study with 294 Caucasian type 1 diabetic patients, the authors found an association with IL-10G*12 allele, a CA repeat microsatellite, in the 5=-flanking region but not with the three SNPs [20]. Moreover, a genetic association between these SNPs in the IL-10 promoter polymorphisms and the type 1 diabetes has been reported in Japanese populations.…”

The cytokine gene polymorphisms (TNF- and #945;, IL-10 And IFN- and #947;) and the role of inflammatory cytokines in diabetic neuropathy

“…40 Studies conducted in France and Spain did not confirm any significant association of DM with different genotypes of IL-10 promoter polymorphisms in Caucasians. [43][44][45] Whereas few reports from Taiwanese, 46 Turkish 47 and Egyptian subjects 48 has shown association of IL-10-1082 homozygous GG with DM cases.…”