Interleukin-10 polymorphisms (rs1800871, rs1800872 and rs1800896) and periodontitis risk: A meta-analysis

Yang, Shuliang; Huang, Shenghong

doi:10.1016/j.archoralbio.2018.10.012

Cited by 13 publications

(14 citation statements)

References 30 publications

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“…A recent meta-analysis showed that rs1800871 and rs1800872 were associated with increased susceptibility to periodontitis in Latin American populations but not in Asian and Caucasian populations. There was also no signi cant association between rs1800896 and periodontitis risk [42]. We con rmed at the genome-wide level the role of gene IL10 with causal variant rs1518110 at locus 1q32.1 for the risk of oral in ammatory traits of PG and TA.…”

Section: Discussionmentioning

confidence: 70%

“…However, the reported results were inconsistent and remained inconclusive [41]. Three SNPs in the promoter region of the IL10 gene, including rs180087, rs1800872, and rs1800896, have been extensively investigated for their association with periodontitis [42]. A recent meta-analysis showed that rs1800871 and rs1800872 were associated with increased susceptibility to periodontitis in Latin American populations but not in Asian and Caucasian populations.…”

Section: Discussionmentioning

confidence: 99%

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Identification of Novel Genome-Wide Associations for Oral Inflammatory Traits

Jin¹,

Yang²,

Zhang³

et al. 2020

Preprint

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Background: Oral diseases impact the majority of the world’s population. The following traits are common in oral inflammatory diseases: mouth ulcers, painful gums, bleeding gums, loose teeth, and toothache. Despite the prevalence of genome-wide association studies, the associations between these traits and common genomic variants, and whether pleiotropic loci are shared by some of these traits remain poorly understood. Methods: In this work, we conducted multi-trait joint analyses based on the summary statistics of genome-wide association studies of these five oral inflammatory traits from the UK Biobank, each of which is comprised of over 10,000 cases and over 300,000 controls. We estimated the genetic correlations between the five traits. We conducted fine-mapping and functional annotation based on multi-omics data to better understand the biological functions of the potential causal variants at each locus. To identify the pathways in which the candidate genes were mainly involved, we applied gene-set enrichment analysis, and further performed protein-protein interaction (PPI) analyses.Results: We identified 39 association signals that surpassed genome-wide significance, including three that were shared between two or more oral inflammatory traits, consistent with a strong correlation. Among these genome-wide significant loci, two were novel for both painful gums and toothache. We performed fine-mapping and identified causal variants at each novel locus. Further functional annotation based on multi-omics data suggested IL10 and IL12A/TRIM59 as potential candidate genes at the novel pleiotropic loci, respectively. Subsequent analyses of pathway enrichment and protein-protein interaction networks suggested the involvement of candidate genes at genome-wide significant loci in immune regulation.Conclusions: Our results highlighted the importance of immune regulation in the pathogenesis of oral inflammatory diseases. Some common immune-related pleiotropic loci or genetic variants are shared by multiple oral inflammatory traits. These findings will be beneficial for risk prediction, prevention, and therapy of oral inflammatory diseases.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Identification of Novel Genome-Wide Associations for Oral Inflammatory Traits

Jin¹,

Yang²,

Zhang³

et al. 2020

Preprint

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“…Periodontitis is essentially a type of inflammatory disease that requires the involvement of multiple anti-or pro-inflammatory factors, such as IL-1, IL-6, and IL-10 15,16 . Many studies have shown that IL-10 is likely to be the most important element among those factors in periodontitis 6,7 , and the inhibition of IL-10 signaling characterizes this disease. In our study, the expression levels of IL-10 were found to be significantly reduced in PDLSCs derived from periodontitis-affected teeth compared to PDLSCs derived from healthy teeth, further confirming the involvement of IL-10 signal inhibition in this disease.…”

Section: Discussionmentioning

confidence: 99%

“…In the past several decades, studies have shown that the occurrence of periodontitis is also closely correlated with a set of genetic factors. Polymorphisms of IL-10 are correlated with a higher risk of periodontitis 6 . It is known that in periodontitis IL-10 can downregulate the synthesis of proinflammatory chemokines and cytokines, gelatinase, nitric oxide, and collagenase, thereby maintaining bone homeostasis 7 .…”

Section: Introductionmentioning

confidence: 99%

Upregulation of IL-10 expression inhibits the proliferation of human periodontal ligament stem cells

2020

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The abnormal increase in proliferation rate of human periodontal ligament stem cells (PDLSCs) is considered to be involved in the pathogenesis of periodontitis, a disease in which the IL-10-mediated anti-inflammatory pathway plays a critical role. This study aimed to investigate the involvement of microRNA-466l in periodontitis and to explore the possible interaction between IL-10 and microRNA-466l. PDLSCs were obtained from periodontitis-affected teeth and healthy control teeth. The expression of microRNA-466l and IL-10 mRNA was measured in PDLSCs using RT-qPCR. The proliferation ability of PDLSCs was analyzed using CCK-8 assays. Overexpression of microRNA-466l in a PDLSC cell line was established using two different types of PDLSCs, and the effect of microRNA-466l overexpression on IL-10 expression and cell proliferation were detected by western blot and CCK-8 assays, respectively. We found that expression levels of microRNA-466l and IL-10 mRNA were significantly lower (P < 0.05) in PDLSCs derived from periodontitis-affected teeth compared to those derived from healthy teeth. However, the cell proliferation ability was significantly higher in the PDLSCs derived from periodontitis-affected teeth. Meanwhile microRNA-466l overexpression decreased cell proliferation rates of both types of PDLSCs and upregulated IL-10 expression. Together, these data suggest that microRNA-466l can upregulate IL-10 and reduce the proliferation rate of PDLSCs.

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“…Interleukin 10 (IL-10) is a cytokine that is involved in the pathogenesis of PD [98]. In a clinical study, it was observed that circulating levels of IL-10 are more reduced in PD patients in comparison to healthy controls [99].…”

Section: Interleukin 10mentioning

confidence: 99%

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

Kozak

Dąbrowska-Żamojcin

Mazurek−Mochol

et al. 2020

JCM

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Periodontal disease (PD) is a chronic inflammatory disease caused by the accumulation of bacterial plaque biofilm on the teeth and the host immune responses. PD pathogenesis is complex and includes genetic, environmental, and autoimmune factors. Numerous studies have suggested that the connection of genetic and environmental factors induces the disease process leading to a response by both T cells and B cells and the increased synthesis of pro-inflammatory mediators such as cytokines. Many studies have shown that pro-inflammatory cytokines play a significant role in the pathogenesis of PD. The studies have also indicated that single nucleotide polymorphisms (SNPs) in cytokine genes may be associated with risk and severity of PD. In this narrative review, we discuss the role of selected cytokines and their gene polymorphisms in the pathogenesis of periodontal disease.

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Interleukin-10 polymorphisms (rs1800871, rs1800872 and rs1800896) and periodontitis risk: A meta-analysis

Cited by 13 publications

References 30 publications

Identification of Novel Genome-Wide Associations for Oral Inflammatory Traits

Identification of Novel Genome-Wide Associations for Oral Inflammatory Traits

Upregulation of IL-10 expression inhibits the proliferation of human periodontal ligament stem cells

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

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