Interleukin-10-producing B-cells in autoimmune bullous diseases

Hashimoto, Takashi; Mizoguchi, Atsushi

doi:10.1111/bjd.15513

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Studies have shown that there are a group of immunosuppressive B cells in a variety of autoimmune diseases [31,32], which are named "regulatory B cells," or Bregs for short [18][19][20]. Bregs can suppress the immune response by secreting cytokines of IL-10, TGF-β, and IL-35, etc., or regulate the immune response by interacting with the target cell membrane surface molecules of FasL, GITRL, and PD-L1 [33,34].…”

Section: Discussion/conclusionmentioning

confidence: 99%

B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding

Ding

et al. 2022

Int Arch Allergy Immunol

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Introduction: We investigated the molecular mechanism by which B lymphocytes regulate Th1/Th2 imbalance to participate in the pulmonary fibrosis in hypersensitivity pneumonia induced by pigeon shedding in rats. Methods: CD19+ rats and CD19− rats were used to construct animal models of fibrotic hypersensitivity pneumonia. DAPT was used to inhibit the Notch signaling pathway. The pathological changes were assessed with HE and Masson staining. Protein level was detected with Western blot. Th1/Th2 ratio was analyzed with flow cytometry. Cytokine levels were measured with ELISA. Results: The pathological changes of pulmonary fibrosis were not obvious in the CD19− rats and after DAPT treatment. Notch signaling pathway proteins, including Notch1, Notch2, Jag1, Jag2, DLL1, and DLL4, in lung tissues of model rats were all significantly upregulated than those in control rats. However, these proteins in CD19− rats were lower in CD19+ rats, suggesting that B cells play a key role in inducing pneumonia. Besides, the Th1/Th2 ratio in the BALF of model rats decreased, which was further reversed by DAPT. However, we found that in CD19− rats, the regulation of the Th1/Th2 ratio by the Notch signaling pathway was lost. Conclusion: Deleting B lymphocytes or blocking the Notch pathway both reversed the Th1/Th2 imbalance in fibrotic hypersensitivity pneumonia and inhibited pulmonary fibrosis.

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Section: Discussion/conclusionmentioning

confidence: 99%

B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding

Ding

et al. 2022

Int Arch Allergy Immunol

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“…7 However, the involvement of IL-10 and IL-35 in BP has not been reported yet. 8 In contrast, there are already reports that IL-10 levels are increased in pemphigus but not in BP. 9 Recently, the association between dipeptidyl peptidase-4 inhibitor (DPP4i) and BP has been well discussed.…”

mentioning

confidence: 94%

“…The possible role of IL‐35 in pemphigus has been reported 7 . However, the involvement of IL‐10 and IL‐35 in BP has not been reported yet 8 . In contrast, there are already reports that IL‐10 levels are increased in pemphigus but not in BP 9 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of IL‐10 and IL‐35 in dipeptidyl peptidase‐4 inhibitor‐related bullous pemphigoid

Kokubu

Takahashi

Kabuto

et al. 2023

Experimental Dermatology

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The association between immunoregulatory cytokines, such as interleukin (IL)‐10 or IL‐35, and dipeptidyl peptidase‐4 inhibitor (DPP4i)‐related bullous pemphigoid (BP) has not been evaluated. Serum IL‐10 and IL‐35 levels were measured in 39 patients with BP (24 males and 15 females; 6 DPP4i‐related and 33 DPP4i‐unrelated BP patients) and 10 healthy controls. The number of CD26+ cells in the dermis around bulla on sections was counted immunohistochemically for 12 patients (six patients with DPP4i‐related BP and six randomly sampled patients with DPP4i‐unrelated BP). Patients with DPP4i‐related BP had lower levels of serum eosinophils (DPP4i‐related vs. DPP4i‐unrelated BP: 476.1 ± 234.0 vs. 911.3 ± 948.8/μL; p = 0.537) and a higher rate of infiltrating CD26+ cells (32.9 ± 7.1% vs. 15.7 ± 4.4%; p = 0.01). There were no significant differences in serum IL‐10 (6.77 ± 0.24 vs. 6.84 ± 0.20 pg/mL), serum IL‐35 (2.63 ± 0.17 vs. 2.63 ± 0.21 pg/mL), serum anti‐BP180NC16a antibodies (67.31 ± 37.4 vs. 76.18 ± 54.59 U/mL) and Bullous Pemphigoid Disease Area Index before treatment in this study. Serum IL‐10 and IL‐35 levels do not increase in patients with BP and may not be a candidate for a therapeutic target for BP. An increase in CD26+ cells might be associated with DPP4i‐related BP.

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Interleukin-10-producing B-cells in autoimmune bullous diseases

Abstract: Linked Article: Kabuto et al. Br J Dermatol 2017; 176:1204–1212.

Cited by 2 publications

References 8 publications

B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding

B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding

Analysis of IL‐10 and IL‐35 in dipeptidyl peptidase‐4 inhibitor‐related bullous pemphigoid

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