Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

Huang, Wei; Song, Juan; Jia, Xiaowei; Chen, Yin-Xue; Shi, Jia; Jiang, Xunping

doi:10.18632/oncotarget.16660

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…For instance, Li et al showed that rs1801320 polymorphism in the RAD51gene could signi cantly enhance the susceptibility to head and neck cancer ). Huang's study revealed that interleukin-10 genetic polymorphisms increases head and neck cancer risk (Huang, Song et al, 2017), UGT1A1 genetic polymorphisms were associated with susceptibility to HNSCC (Lacko, Roelofs et al, 2010). Besides, Li found that genetic polymorphisms in NFKB1 are associated with a decreased risk in head and neck cancers .…”

Section: Discussionmentioning

confidence: 99%

The genetic variants of LINC-PINT are related to head and neck squamous cell carcinoma susceptibility in Chinese population

Xue¹,

Dong²,

Wang³

et al. 2021

Preprint

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Background: Head and neck squamous cell carcinoma (HNSCC) is the most leading incident tumor worldwide. Genetic factors act crucial role in the HNSCC progression. Our study is intent to explore the correlation of LINC-PINT polymorphism with the risk of HNSCC in Chinese population.Methods: The case-control study (including 537 HNSCC cases and 533 controls) was performed to determine the relationship between LINC-PINT polymorphisms and HNSCC susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the associations.Results: The current study indicated that rs157916 and rs7781295 in the LINC-PINT gene have a strong significant correlation with HNSCC risk (OR 1.32, p = 0.042; OR 1.31, p = 0.016). Stratification analyses showed that rs157916 is related to the increased risk of HNSCC in age ≤ 46 years (OR 1.56, p = 0.029). Rs157916, rs16873842, rs7801029, and rs7781295 exhibited an enhanced risk of HNSCC in men (OR 1.82, p = 0.004; OR 1.61, p = 0.028; OR 1.53, p = 0.047; OR 1.62, p = 0.021). Besides, we found that rs16873842 significantly increased the risk of Nasopharyngeal SCC (OR 4.04, p = 0.015). Rs157916 (OR 1.39, p = 0.028) and rs7781295 (OR 1.30, p = 0.028) had a high susceptibility to Thyroid SCC.Conclusions: This research indicated that polymorphisms in the LINC-PINT gene are significantly associated with an increased susceptibility to HNSCC, which suggest that LINC-PINT polymorphisms have a significant role in prevention and diagnosis of HNSCC.

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Section: Discussionmentioning

confidence: 99%

The genetic variants of LINC-PINT are related to head and neck squamous cell carcinoma susceptibility in Chinese population

Xue¹,

Dong²,

Wang³

et al. 2021

Preprint

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Section: Discussionmentioning

confidence: 99%

“…A previous study suggested that the secretion of IL-10 is determined largely (74%) by heritable factors 23 . Several studies have found an association between the IL-10 -1082 G/A polymorphism and oral cancer,head and neck cancer 24 , 25 . Because meta-analysis is a suitable method to evaluate small effects in genetic association studies, we designed this study to systematically evaluate the association of the IL-10 -1082 G/A polymorphism with HCC risk.…”

Section: Discussionmentioning

confidence: 99%

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

Wang¹,

Hu²

2020

Afr H. Sci.

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Background: Inconsistent results have been reported from studies investigating the relationship of the interleukin-10 (IL-10) -1082 G/A polymorphism and the susceptibility of hepatocellular carcinoma (HCC). Therefore, a thorough literature review of relatedstudies was performed in this meta-analysis to examine the association of the interleukin-10(IL-10) -1082 G/A poly- morphism with HCC susceptibility. Methods: Electronic databases were searched for literature on the relationship between interleukin-10(IL-10) -1082 G/A poly- morphism and the risk of HCC in accordance with the inclusion and exclusion criteria. The selected studies were analyzed using the Stata 12.0 software. Finally, the strength of the associations was evaluated using the odds ratio (OR) and 95% confidence intervals (95% CI). Results: A total of six case-control studies were enrolled into the current meta-analysis, which included a total of 911 patients and 1889 control subjects. Our data revealed no association between the IL-10 -1082 G/A polymorphism and the risk of HCC (GG vs AA:OR=0.84, 95%CI=0.57-1.25; AG vs AA:OR=0.85, 95%CI=0.70-1.05; Dominant model: OR=0.85, 95%CI=0.70- 1.03; and Recessive model: OR=0.92, 95%CI = 0.64-1.32). Similarly, no association was found in sub-group analysis based on ethnicity. Conclusion: The results of our study suggest no association between IL-10 -1082 G/A polymorphism and the risk of HCC. Keywords: Hepatocellular carcinoma; IL-10 polymorphism; risk analysis.

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“…Association between rs1800896 polymorphism and head and neck cancer risk and its clinical stages in Caucasian and Asiatic evaluated by meta-analysis gave a significant association with head and neck cancer risk but not with the clinical stages [91]. Other analysis reports significant associations between the IL10 −1082A > G and IL10 −819 T > C polymorphism and increased risks of head and neck cancer similar population [92].…”

Section: Diseasementioning

confidence: 99%

IL10 as Cancer Biomarker

González‐Garza¹,

Cruz-Vega²,

Maldonado‐Bernal³

2021

Translational Research in Cancer

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Chronic inflammation can trigger events that would induce the malignant transformation of cells and carcinogenesis. Cytokines play a crucial role and can control the development and multiplication of cancerous cells. However, clinical data present controversy about the participation of these proteins in the establishment and development of cancer. Interleukin 10 (IL-10), a potent anti-inflammatory cytokine, has been the subject of multiple studies. Several studies have reported that IL-10 has pro-and antitumor effects. Elevated levels of IL-10 are associated with increased tumor growth with poor prognosis and drug resistance. However, this cytokine has both tumor-promoting and tumor-inhibiting properties. In vitro and in vivo studies report mechanisms by which IL-10 expression downregulates class I, which results in the control of the metastatic disease. IL-10 also inhibits tumorigenesis via downregulation of other cytokines. The variation observed could be the result of concentration ranges of this protein, genetic polymorphism, or both. The value obtained may serve as a biomarker indicative of tumor development and its prognosis.

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Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

Cited by 10 publications

References 42 publications

The genetic variants of LINC-PINT are related to head and neck squamous cell carcinoma susceptibility in Chinese population

The genetic variants of LINC-PINT are related to head and neck squamous cell carcinoma susceptibility in Chinese population

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

IL10 as Cancer Biomarker

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