2005
DOI: 10.1161/01.res.0000177893.24574.13
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Interleukin-10 Suppresses Tissue Factor Expression in Lipopolysaccharide-Stimulated Macrophages via Inhibition of Egr-1 and a Serum Response Element/MEK-ERK1/2 Pathway

Abstract: Abstract-Atherosclerosis is considered to be an inflammatory disease. Tissue factor (TF), a prothrombotic molecule expressed by various cell types within atherosclerotic plaques, is thought to play an essential role in thrombus formation after atherosclerotic plaque rupture. Recent studies suggest that the antiinflammatory cytokine interleukin-10 (IL-10) has many antiatherosclerotic properties. Therefore, the effects of IL-10 on TF expression in response to inflammation were investigated. Mouse macrophages wer… Show more

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Cited by 49 publications
(39 citation statements)
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“…Although PMA alone is known to induce the activation of Sp1 in T cells (4), both PMA and PHA have been shown to activate Egr1 in CEM cells (T cell line) (26). IL-10 has been previously shown to negatively regulate LPS-stimulated Egr1 expression in mouse macrophages (27). Thus, it would be interesting to study the effect IL-10 on Egr1 induced expression of hsa-miR-106a.…”
Section: Discussionmentioning
confidence: 99%
“…Although PMA alone is known to induce the activation of Sp1 in T cells (4), both PMA and PHA have been shown to activate Egr1 in CEM cells (T cell line) (26). IL-10 has been previously shown to negatively regulate LPS-stimulated Egr1 expression in mouse macrophages (27). Thus, it would be interesting to study the effect IL-10 on Egr1 induced expression of hsa-miR-106a.…”
Section: Discussionmentioning
confidence: 99%
“…The induction of Egr-1 has been demonstrated in cells exposed to various stimuli, including phorbol ester, ionizing radiation, inflammation, oxidative agents, and mechanical stretch/relaxation [9,10] . Its target genes include cytokine, chemokines, cell adhesion molecules, and immunoreceptors [9][10][11][12] . The human monocyte cell line THP-1 is often used as a model for tissue macrophages.…”
Section: Discussionmentioning
confidence: 99%
“…1). Tissue factor plays a key role in the development of vegetations, since it is the primary biological initiator of the coagulation cascade (Kamimura et al 2005;Bea et al 2003). S. aureus is able directly to induce tissue factor expression in endothelial cells (Veltrop et al 1999;Mattson et al 2002).…”
Section: Infective Endocarditismentioning
confidence: 99%