Interleukin-11 in Pathologies of the Nervous System

Abstract

The study of the role of cytokines in various pathological conditions of the body is a topical area in modern biomedicine. Understanding the physiological roles played by cytokines will aid in finding applications for them as pharmacological agents in clinical practice. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been increased interest in this cytokine in recent years. IL-11 has been shown to correct inflammatory pathways in the epithelial tissues of the respiratory system, where the main events occur during SARS-CoV-2 infection. Further research in this direction will probably support the use of this cytokine in clinical practice. The cytokine plays a significant role in the central nervous system; local expression by nerve cells has been shown. Studies show the involvement of IL-11 in the mechanisms of development of a number of pathologies of the nervous system, and therefore it seems relevant to generalize and analyze the experimental data obtained in this direction. This review summarizes information that shows the involvement of IL-11 in the mechanisms of development of brain pathologies. In the near future this cytokine will likely find clinical application for the correction of mechanisms that are involved in the formation of pathological conditions of the nervous system.

Almost 50 Years of Monomeric Extracellular Ubiquitin (eUb)

“…This fact may have significant clinical repercussions since there is evidence that IL-11 is involved in the development of pathological conditions of the nervous system. The role of IL-11 in Alzheimer’s disease, autoimmune encephalomyelitis, multiple sclerosis, ischemic brain damage, and other diseases is studied in animal models [ 71 ]. In the case of relapsing–remitting multiple sclerosis (RRMS), IL-11 regulates inflammatory cell trafficking to the central nervous system (CNS) [ 72 ].…”

Almost 50 Years of Monomeric Extracellular Ubiquitin (eUb)

“…This fact may have significant clinical repercussions since there is evidence that IL-11 is involved in the development of pathological conditions of the nervous system. The role of IL-11 in Alzheimer's disease, autoimmune encephalomyelitis, multiple sclerosis, ischemic brain damage, and other diseases is studied in animal models [72]. In the case of relapsing-remitting multiple sclerosis (RRMS), IL-11 regulates inflammatory cell trafficking to the central nervous system (CNS) [73].…”