Interleukin-11 in Pathology of the Nervous System

Abstract

The study of the role of cytokines in various pathological conditions of the body is one of the topical areas of modern biomedicine. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been an increased interest in the cytokine in recent years. The cytokine plays a significant role in the central nervous system; local expression of this cytokine by nerve cells has been shown. Studies show the involvement of IL-11 in the mechanisms of development of a number of pathologies of the nervous system. The review summarizes information that shows the involvement of IL-11 in the mechanisms of development of brain pathologies. Probably, in the near future, this cytokine will be able to find clinical application in the correction of mechanisms that are involved in the formation of pathological conditions of the nervous system.

Engagement of AKT and ERK signaling pathways facilitates infection of human neuronal cells with West Nile virus

“…IL-11 has important roles in inflammation, fibrosis, and carcinoma, allowing the development of novel therapeutics with the potential for clinical targeting of IL-11 signaling in multiple diseases. 42 , 43 Studies were performed to define the IL-11 regulation by viruses and its implications for viral pathogenesis. It has been previously demonstrated that up-regulation of IL-11 was observed at 72 h post-infection of cCyprinid herpesvirus.…”