2017
DOI: 10.1038/s41467-017-00594-5
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interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration

Abstract: Unlike mammals, Xenopus laevis tadpoles possess high ability to regenerate their lost organs. In amphibians, the main source of regenerated tissues is lineage-restricted tissue stem cells, but the mechanisms underlying induction, maintenance and differentiation of these stem/progenitor cells in the regenerating organs are poorly understood. We previously reported that interleukin-11 (il-11) is highly expressed in the proliferating cells of regenerating Xenopus tadpole tails. Here, we show that il-11 knockdown … Show more

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Cited by 39 publications
(57 citation statements)
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“…Consistent with this, mice deficient for il-6, gp130 or stat3 exhibit impaired liver regeneration (Cressman et al, 1996;Taub, 2004). IL-11, another IL-6 family member, is induced early in Xenopus tail regeneration and is required for this process (Tsujioka et al, 2017). JAK/STAT signaling is also crucial for the regeneration of diverse zebrafish cells and tissues, including cardiomyocytes, the retina and inner ear hair cells (Fang et al, 2013;Liang et al, 2012;Zhao et al, 2014).…”
Section: Parallels In Jak/stat Signaling Across Tissues and Across Spmentioning
confidence: 66%
“…Consistent with this, mice deficient for il-6, gp130 or stat3 exhibit impaired liver regeneration (Cressman et al, 1996;Taub, 2004). IL-11, another IL-6 family member, is induced early in Xenopus tail regeneration and is required for this process (Tsujioka et al, 2017). JAK/STAT signaling is also crucial for the regeneration of diverse zebrafish cells and tissues, including cardiomyocytes, the retina and inner ear hair cells (Fang et al, 2013;Liang et al, 2012;Zhao et al, 2014).…”
Section: Parallels In Jak/stat Signaling Across Tissues and Across Spmentioning
confidence: 66%
“…While there were 20 KEGG pathways significantly enriched in X1, only four pathways were enriched in X2 ( Figure 2F and Supplementary Table S5 ). To confirm the results of the bioinformatics analyses, we quantified the expressions of several genes related to tissue regeneration ( Kroehne et al, 2011 ; Tsujioka et al, 2017 ; Galvao et al, 2018 ; Yu et al, 2019 ). prg4a and klf11 were indeed upregulated only in the lesioned hemisphere ( Figure 2G ), while gfap and il6st were so in both hemispheres ( Figure 2H ).…”
Section: Resultsmentioning
confidence: 98%
“…The following analysis was performed essentially as described previously [58] with modifications. In brief, the reads were mapped to the mouse genome GRCm38 [59] using HISAT2 [60, 61].…”
Section: Methodsmentioning
confidence: 99%