Interleukin‐11, interleukin‐1<i>β</i>, interleukin‐12 and the pathogenesis of inflammatory periodontal diseases

Yücel, Özlem Özer; Berker, Ezel; Gariboglu, S.; Otlu, Harika

doi:10.1111/j.1600-051x.2008.01212.x

Cited by 64 publications

(75 citation statements)

References 45 publications

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“…It has been proposed that an 9 increase in IL-12 production could be an event associated with the inhibition of pro inflammatory cytokines, such as TNF-α (47). IL-12 is considered a link between innate and adaptive immunity (48,49), and may be related to the pathogenesis of periodontal disease (50)(51)(52). Another interesting observation in the present study is that the production of the anti-inflammatory cytokine IL-10 was increased in response to LDD, possibly potentiating its beneficial effects to the host (53).…”

Section: Actinomycetemcomitans Lps (42) In Other Experimental Systemsupporting

confidence: 52%

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

et al. 2011

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Doxycycline is an antibiotic used in the treatment of a variety of inflammatory conditions, including periodontitis. Apart from its antimicrobial properties, this drug also has independent antiinflammatory effects at sub-antimicrobial doses. The present study aimed to investigate the effects of low-doses of doxycycline (LDD) on cytokine production by human monocytic cells challenged with the periodontal pathogen Aggregatibacter actinomycetemcomitans, for up to 6h. The simultaneous regulation of 12 cytokines were measured by a Human Cytokine Array Kit. To validate the array findings, selected cytokines were also measured by enzyme-linked immunosorbant assay (ELISA). A. actinomycetemcomitans stimulated the production of tumor necrosis factor (TNF)-, interleukin (IL)-1 , IL-1 , IL-6 and IL-8 by the cells after 6h of challenge, and doxycycline significantly inhibited this effect. The kinetics of this regulation demonstrated an early (within 2h) and significant (P<0.05) inhibition of pro-inflammatory cytokines, with a mild (0.5-fold) up-regulation of the anti-inflammatory cytokine IL-10. The results indicate that LDD acts as an anti-inflammatory agent in human monocytic cells stimulated with A. actinomycetemcomitans. This model provides clear evidence that some of the clinically proven benefits of LDD may be related to its ability to regulate inflammatory mediator release by monocytic cells. This property may contribute to the clinically proven benefits of this antibiotic as an adjunctive treatment for periodontitis.

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Section: Actinomycetemcomitans Lps (42) In Other Experimental Systemsupporting

confidence: 52%

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

et al. 2011

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“…Immune response of the periodontal tissues to infection is influenced by environmental factors as well as genetic factors (1). The complex cytokine network that mediates the immune response includes pro-inflammatory cytokines, antiinflammatory cytokines and specific cytokine receptors.…”

Section: Introductionmentioning

confidence: 99%

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Toker¹,

Görgün²,

Korkmaz³

2017

Cent Eur J Public Health

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SUMMARYObjective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-κB(NF-κB). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-κB1-94ins/del)) and chronic/aggressive periodontitis.Methods: Forty-five patients with chronic periodontitis (CP), 58 patients with aggressive periodontitis (AP) and 38 periodontally healthy subjects were included in this study. Genomic DNA was isolated from whole blood samples. The NF-κB, IL-6, and IL-10 polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: Among subjects for the ins/ins genotypes of NF-κB1 gene, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis group than in healthy controls (p = 0.023). A statistically significant difference in genotyping frequencies between AP group and healthy controls was observed for the IL-6 gene. The AA genotype of IL-10 was overrepresented in CP and AP groups compared to healthy controls (OR = 9.93, 95% CI: 2.11-46.7, OR = 5.7, 95% CI: 1.22-26.89, respectively).Conclusions: Within the limits of this study, it can be concluded that the IL-10 (-597) AA genotype is associated with susceptibility to chronic/ aggressive periodontitis and IL-6 (-174) GG genotypes and G allele seems to be associated with aggressive periodontitis.Clinical relevance: The results of the current study indicate that IL-6 and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-κB1 ins/ins genotypes.

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“…Several other studies have attempted to determine the IL-12 profile in periodontal disease [24][25][26]. Although the results are contradictory, there is evidence that IL-12 plays a potential role in the progression of periodontal inflammation by inducing a Th1 response [26,27].…”

Section: The Role Of Th1/th2/th17 Cytokines In Periodontal Diseasementioning

confidence: 99%

“…It was reported that the twice-weekly administration of recombinant human IL-11 in the developing periodontal disease model acted by blocking the cytokines most associated with inflammation, leaded to a reduction in both attachment loss and bone resorption [50]. In a study which we aimed to determine the possible role of IL-11 in periodontal pathogenesis, together with the proinflammatory cytokines IL-1β and IL-12, lower levels of IL-11 were detected in GCF of chronic periodontitis patients in comparison with gingivitis and healthy subjects [26]. Moreover, IL-11: IL-1β ratio became progressively lower with increasing probing depth.…”

Section: Th2 Cytokinesmentioning

confidence: 99%

“…Clinical studies have illustrated that the amount of IL-1β is much higher in GCF in periodontal pockets or in the underlying inflamed gingival tissue than at healthy sites. Furthermore, IL-1β levels are higher in active periodontitis sites than in stable sites [16,26,29] It is known that TNF-α induces bone and extracellular matrix resorption by activating the osteoclasts in a similar way with IL-1 [30]. Monocytes and macrophages are the potent cell types producing TNF-α.…”

Section: Th1 Cytokinesmentioning

confidence: 99%

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Inflammatory Cytokines and the Pathogenesis of Periodontal Disease

Yücel¹

2015

Immunome Res

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Interleukin‐11, interleukin‐1β, interleukin‐12 and the pathogenesis of inflammatory periodontal diseases

Abstract: Our data showed that IL-11 levels are significantly decreased in GCF from sites with periodontitis compared with G and healthy sites. Because of the possible preventive effect of IL-11 on inflammation, IL-11 may be an important factor in the therapeutic modulation of periodontal disease.

Cited by 64 publications

References 45 publications

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Inflammatory Cytokines and the Pathogenesis of Periodontal Disease

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