2022
DOI: 10.23822/eurannaci.1764-1489.180
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Interleukin 13 gene polymorphism and susceptibility to asthma: a meta-regression and meta-analysis

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Cited by 15 publications
(14 citation statements)
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References 19 publications
(19 reference statements)
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“…[5][6][7][8][9][10] By analogy, we theorized that differences in the host's proclivity to preserve versus degrade trained immunity in response to repetitive exposures to aeroallergens may contribute to the resilient or adaptive versus maladaptive phenotypes, respectively (Fig 1, A). This framework is supported by genome-wide association studies in persons with atopic diseases (eg, ARC, AA, and atopic dermatitis) that identified 2 major classes of genes that influence (1) epithelial integrity (Epi integrity ; eg, FLG and IL33) and (2) inflammatory responses, such as T H 2 skewing (eg, IL13) [11][12][13][14][15][16][17] (Fig 1, B). Hence, we posited that maladaptation may be mediated by 2 factors: ineffective trained immunity manifesting as ineffectual airway Epi integrity and a proinflammatory profile.…”
mentioning
confidence: 84%
“…[5][6][7][8][9][10] By analogy, we theorized that differences in the host's proclivity to preserve versus degrade trained immunity in response to repetitive exposures to aeroallergens may contribute to the resilient or adaptive versus maladaptive phenotypes, respectively (Fig 1, A). This framework is supported by genome-wide association studies in persons with atopic diseases (eg, ARC, AA, and atopic dermatitis) that identified 2 major classes of genes that influence (1) epithelial integrity (Epi integrity ; eg, FLG and IL33) and (2) inflammatory responses, such as T H 2 skewing (eg, IL13) [11][12][13][14][15][16][17] (Fig 1, B). Hence, we posited that maladaptation may be mediated by 2 factors: ineffective trained immunity manifesting as ineffectual airway Epi integrity and a proinflammatory profile.…”
mentioning
confidence: 84%
“…Also, a recently published meta-analysis concluded that rs20541 polymorphism is a potential risk factor for asthma in people from different ethnicities. 15 We couldn't find evidence for association between rs20541 SNP polymorphism and either IgE levels or allergic rhinitis. Similarly, Lu et al, 3 did not find a significant association between IL13 SNPs and allergic rhinitis among Chinese children with asthma.…”
Section: Discussionmentioning
confidence: 79%
“…A number of gene variants and genetic background patterns have been associated with the manifestation or severity of atopic states and overt allergic disorders. Several of the affected genes encode proteins physiologically involved in the regulation of MC development, such as KIT, IL-4, or IL-6, the production of IgE, and/or the regulation of expression of the IgE receptor on MC, where IL-4, the IL-4 receptors, and IL-13 may play a role [ 54 , 55 , 56 ]. Other genes (variants) encode for proteins that are produced in MC and/or other immune cells and are involved in the regulation of vascular stability or dysfunction, such as angiotensinogen, angiotensin-converting enzymes, or chymase [ 8 , 20 , 57 , 58 ].…”
Section: Predisposing Genetic Variants and Patterns And Clonal Diseas...mentioning
confidence: 99%