Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum<i>in vivo</i>

Hong, Ah Reum; Jang, J; Chung, Young Cheul; Won, So-Yoon; Jin, Byung Kwan

doi:10.5607/en21032

Cited by 8 publications

(3 citation statements)

References 66 publications

(96 reference statements)

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“…Interleukin-13 (IL-13), functions in the CNS as an anti-inflammatory cytokine and is expressed by reactive microglia and can produce both beneficial and harmful effects on the local environment [ 28 ]. The IL-13 inflammatory pathway has been shown to modulate potassium calcium-activated channel subfamily N member 4 (KCNN4) which codes for K Ca 3.1 [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period

Hedley,

Gomez,

Kecelioglu

et al. 2024

J Neuroinflammation

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Respiratory infections are one of the most common causes of illness and morbidity in neonates worldwide. In the acute phase infections are known to cause wide-spread peripheral inflammation. However, the inflammatory consequences to the critical neural control centres for respiration have not been explored. Utilising a well characterised model of neonatal respiratory infection, we investigated acute responses within the medulla oblongata which contains key respiratory regions. Neonatal mice were intranasally inoculated within 24 h of birth, with either Chlamydia muridarum or sham-infected, and tissue collected on postnatal day 15, the peak of peripheral inflammation. A key finding of this study is that, while the periphery appeared to show no sex-specific effects of a neonatal respiratory infection, sex had a significant impact on the inflammatory response of the medulla oblongata. There was a distinct sex-specific response in the medulla coincident with peak of peripheral inflammation, with females demonstrating an upregulation of anti-inflammatory cytokines and males showing very few changes. Microglia also demonstrated sex-specificity with the morphology of females and males differing based upon the nuclei. Astrocytes showed limited changes during the acute response to neonatal infection. These data highlight the strong sex-specific impact of a respiratory infection can have on the medulla in the acute inflammatory phase.

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Section: Resultsmentioning

confidence: 99%

Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period

Hedley,

Gomez,

Kecelioglu

et al. 2024

J Neuroinflammation

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“…Increased IL-13 release from reactive microglia has also been shown to be neurotoxic following lipopolysaccharide injection. In this model, increased IL-13 immunoreactivity was further associated with astrocyte damage and blood brain barrier (BBB) disruption (Hong et al, 2022). Thus, it is essential to consider the function of IL-13 in the context of specific disorders and disease states, including the state of disease progression, and the specific function of increased NAc IL-13 in the EcoHIV model remains a promising area for future study.…”

Section: Discussionmentioning

confidence: 99%

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

Xie,

Namba,

Buck

et al. 2024

Preprint

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HIV infection is an ongoing global health issue despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. It is increasingly evident that ART may act independently or in combination with HIV infection to alter immune state, though this is difficult to disentangle in the clinical population. Thus, these experiments used multiplexed chemokine/cytokine arrays to assess peripheral (plasma) and brain (nucleus accumbens; NAc) expression of immune targets in the presence and absence of ART treatment in the EcoHIV mouse model. The findings identify effects of EcoHIV infection and of treatment with bictegravir (B), emtricitabine (F) and tenofovir alafenamide (TAF) on expression of numerous immune targets. In the NAc, this included EcoHIV-induced increases in IL-1α and IL-13 expression and B/F/TAF-induced reductions in KC/CXCL1. In the periphery, EcoHIV suppressed IL-6 and LIF expression, while B/F/TAF reduced IL-12p40 expression. In absence of ART, IBA-1 expression was negatively correlated with CX3CL1 expression in the NAc of EcoHIV-infected mice. These findings identify distinct effects of ART and EcoHIV infection on peripheral and central immune factors and emphasize the need to consider ART effects on neural and immune outcomes.

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“…While this may protect neurons from excitotoxic death following brain injury [56], this effect could produce cognitive impairments akin to those observed in HAND [57]. Increased IL-13 release from reactive microglia has also been shown to be neurotoxic following lipopolysaccharide injection, which was further associated with astrocyte damage and blood-brain barrier (BBB) disruption [58]. Thus, it is essential to consider the function of IL-13 in the context of specific disorders and disease states, including the state of disease progression.…”

Section: Discussionmentioning

confidence: 99%

Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection

Xie,

Namba,

Buck

et al. 2024

Cells

View full text Add to dashboard Cite

HIV infection is an ongoing global health issue, despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. It is increasingly evident that ART may act independently or in combination with HIV infection to alter the immune state, though this is difficult to disentangle in the clinical population. Thus, these experiments used multiplexed chemokine/cytokine arrays to assess peripheral (plasma) and brain (nucleus accumbens; NAc) expression of immune targets in the presence and absence of ART treatment in the EcoHIV mouse model. The findings identify the effects of EcoHIV infection and of treatment with bictegravir (B), emtricitabine (F), and tenofovir alafenamide (TAF) on the expression of numerous immune targets. In the NAc, this included EcoHIV-induced increases in IL-1α and IL-13 expression and B/F/TAF-induced reductions in KC/CXCL1. In the periphery, EcoHIV suppressed IL-6 and LIF expression, while B/F/TAF reduced IL-12p40 expression. In the absence of ART, IBA-1 expression was negatively correlated with CX3CL1 expression in the NAc of EcoHIV-infected mice. These findings identify distinct effects of ART and EcoHIV infection on peripheral and central immune factors and emphasize the need to consider ART effects on neural and immune outcomes.

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Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatumin vivo

Cited by 8 publications

References 66 publications

Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period

Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection

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