Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice

Di Castro, Maria Amalia; Garofalo, Stefano; Mormino, Alessandro; Carbonari, Laura; Di Pietro, Erika; De Felice, Eleonora; Catalano, Myriam; Maggi, Laura; Limatola, Cristina

doi:10.1016/j.bbi.2023.11.015

Cited by 5 publications

(1 citation statement)

References 93 publications

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“…On the other hand, other neurotoxic cytokines such as IL15 and IL17 were not even measurable in the current study group. According to a study conducted by Di Castro et al [52], IL15, a proin ammatory cytokine, has been found to have a negative impact on episodic memory. IL17 plays a signi cant role in promoting in ammation, disrupting the blood-brain barrier (BBB), and causing tissue damage in conditions such as Alzheimer's disease [53].…”

Section: Neurotoxic Cytokines/chemokines In Amci and Mcodymentioning

confidence: 99%

Is Amnestic Mild Cognitive Impairment a Neuro-Immune Condition?

Tran-Chi,

Maes,

Nantachai

et al. 2024

Preprint

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Objectives The pathophysiology of amnestic Mild Cognitive Impairment (aMCI) is largely unknown, although some papers found signs of immune activation. To assess the cytokine network in aMCI after excluding patients with major depression (MDD) and to examine the immune profiles of quantitative aMCI (qMCI) and distress symptoms of old age (DSOA) scores. Design: A case-control study. Setting: Department of Psychiatry of a University Hospital, Bangkok, Thailand. Participants : 61 Thai aMCI participants and 60 healthy old adults (both without MDD). Measurements : The Bio-Plex Pro human cytokine 27-plex test kit was used to assay cytokines/chemokines/growth factors in fasting plasma samples. Results aMCI is characterized by significant general immunosuppression, and reductions in T helper 1 (Th)1 and T cell growth profiles, the immune-inflammatory responses system, interleukin (IL)1β, IL6, IL7, IL12p70, IL13, GM-CSF, and MCP-1. These 7 cytokines/chemokines exhibit neuroprotective effects at physiologic concentrations. In multivariate analyses, three neurotoxic chemokines, CCL11, CCL5, and CXCL8, emerged as significant predictors of aMCI. Logistic regression showed that aMCI was best predicted by combining IL7, IL1β, MCP-1, years of education (all inversely associated) and CCL5 (positively associated). We found that 38.2% of the variance in the qMCI score was explained by IL7, IL1β, MCP-1, IL13, years of education (inversely associated) and CCL5 (positively associated). The DSOA was not associated with any immune data. Discussion A dysbalance between lowered levels of neuroprotective cytokines and chemokines, and relative increases in neurotoxic chemokines are key factors in aMCI. Future MCI research should always control for the confounding effects of affective symptoms.

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Section: Neurotoxic Cytokines/chemokines In Amci and Mcodymentioning

confidence: 99%

Is Amnestic Mild Cognitive Impairment a Neuro-Immune Condition?

Tran-Chi,

Maes,

Nantachai

et al. 2024

Preprint

View full text Add to dashboard Cite

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Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Kale,

Wankhede,

Bishoyi

et al. 2025

Neuroscience

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Cytokine dysregulation in amnestic mild cognitive impairment

Tran-Chi,

Maes,

Nantachai

et al. 2024

Sci Rep

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The pathophysiology of amnestic Mild Cognitive Impairment (aMCI) is largely unknown, although some papers found signs of immune activation. To assess the cytokine network in aMCI after excluding patients with major depression (MDD) and to examine the immune profiles of quantitative aMCI (qMCI) and distress symptoms of old age (DSOA) scores. A case-control study was conducted on 61 Thai aMCI participants and 60 healthy old adults (both without MDD). The Bio-Plex Pro human cytokine 27-plex test kit was used to assay cytokines/chemokines/growth factors in fasting plasma samples. aMCI is characterized by a significant immunosuppression, and reductions in T helper 1 (Th)1 and T cell growth profiles, the immune-inflammatory responses system, interleukin (IL)1β, IL6, IL7, IL12p70, IL13, GM-CSF, and MCP-1. These 7 cytokines/chemokines exhibit neuroprotective effects at physiologic concentrations. In multivariate analyses, three neurotoxic chemokines, CCL11, CCL5, and CXCL8, emerged as significant predictors of aMCI. Logistic regression showed that aMCI was best predicted by combining IL7, IL1β, MCP-1, years of education (all inversely associated) and CCL5 (positively associated). We found that 38.2% of the variance in the qMCI score was explained by IL7, IL1β, MCP-1, IL13, years of education (inversely associated) and CCL5 (positively associated). The DSOA was not associated with any immune data. An imbalance between lowered levels of neuroprotective cytokines and chemokines, and relative increases in neurotoxic chemokines are key factors in aMCI. Future MCI research should always control for the confounding effects of affective symptoms. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-73099-z.

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Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice

Cited by 5 publications

References 93 publications

Is Amnestic Mild Cognitive Impairment a Neuro-Immune Condition?

Is Amnestic Mild Cognitive Impairment a Neuro-Immune Condition?

Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Cytokine dysregulation in amnestic mild cognitive impairment

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