Interleukin-16 Gene Polymorphisms rs4778889, rs4072111, rs11556218, and Cancer Risk in Asian Populations: A Meta-Analysis

ZhaoYanhui,; TaoLi,; WangBing,; NiePing,; TangYanmei,; ZhuMin,

doi:10.1089/gtmb.2013.0386

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…In agreement with our results, two other metaanalyses published in 2014 did not find a significant association between rs4778889 and rs4072111 of IL16 and cancer. However, these same studies observed a statistically significant association between rs11556218 and cancer, an association observed in our study with the addition of new studies published after these metaanalyses results [41][42][43][44]. The SNP rs11556218, consisting of a substitution of the T nucleotide by a G, is located in the exon region of the gene and results in a modification of the pro-IL-16 PDZ2 domain (IL-16 isoform with 631 amino acids) and npro-IL-16 (neuronal IL-16 isoform with 1331 amino acids).…”

Section: Discussionsupporting

confidence: 62%

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

et al. 2020

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Introduction: Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD). Single nucleotide polymorphisms (SNPs) in IL16 were associated with diseases. Thus, we conducted a systematic review and meta-analysis to evaluate possible associations between IL16 rs4778889, rs11556218, rs4072111, and rs1131445 SNPs and the risk for cancer or CVD. Materials and Methods: This study was performed according to the PRISMA statement. Medline, Web of Science, and Scopus databases were systematically reviewed, and a meta-analysis was conducted. Results: The analysis comprised 6386 individuals with cancer and 2415 with CVD. The SNP rs11556218 was significantly associated with an increased risk for cancer in Chinese in different genetic inheritance models. Also, to the best of our knowledge, this is the first meta-analysis to show an association of rs4778889 with an increased risk of gastric cancer and rs11556218 with an increased risk of CVD in Chinese. Conclusions: Our meta-analysis suggested that the SNPs rs11556218 and rs4778889 of IL16 were associated with an increased risk for cancer in Chinese and rs11556218 with increased risk for CVD in Chinese, highlighting the need for further studies on the impact of these polymorphisms on cancer treatment and surveillance.

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Section: Discussionsupporting

confidence: 62%

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

et al. 2020

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“…The positive association was also observed in nasopharyngeal carcinoma 31 32 , prostate cancer 34 , and glioma 37 . Meta-analysis conducted by two independent groups confirmed these findings of IL16 rs11556218 increasing cancer risk 41 42 . In agreement with these results, we found that the rs11556218 TG/GG genotypes had a 1.66-fold increased risk of developing OS.…”

Section: Discussionmentioning

confidence: 57%

“…Our results were consistent with the negative effect. We failed to find any association between IL16 rs4778889 polymorphism and OS risk, which was verified by three independent meta-analyses 41 42 43 .…”

Section: Discussionmentioning

confidence: 78%

Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Tang

Wang

Xie

et al. 2016

Sci Rep

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Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patients with OS and 402 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. Plasma IL16 level was measured by enzyme-linked immunosorbent assay. Rs11556218 was associated with an increased risk of OS in heterozygote comparison (adjusted OR = 1.65, 95% CI, 1.23–2.21, P < 0.001), dominant model (adjusted OR = 1.66, 95% CI, 1.24–2.21, P < 0.001), and allele comparison (adjusted OR = 1.44, 95% CI, 1.14–1.81, P = 0.002). Moreover, rs11556218 TG/GG genotypes were associated with higher levels of IL16 as compared to TT genotype (P = 0.03). However, no significant association of rs4778889 and rs4072111 and OS was found. These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.

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“…This variant was also associated with the risk of osteoporosis in postmenopausal women, although there was no significant alteration in serum cytokine levels [40]. This SNP has also been associated with many types of cancer [41]. In patients with osteosarcoma, IL16 variants were related to higher levels of IL-16 and, consequently, in the effects in the production of other tumor-related inflammatory cytokines, such as TNF-α and IL-1β [42].…”

Section: Plos Onementioning

confidence: 99%

Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

et al. 2020

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Periodontitis (PD) is a chronic inflammatory process resulting from the relationship of the immune response with the components in dental plaque. Cytokines and their genetic polymorphisms seem to be involved in the immunopathogenesis of this disease. This study aimed to evaluate the correlation of IL16 polymorphism with PD. A case-control study was conducted in a sample of individuals from southern Brazil. The genotyping of IL16, rs11556218 T>G, rs4072111 C>T e rs4778889 T>C, was performed using the PCR-RFLP methodology. The serum level of IL-16 was determined using an IL-16 ELISA kit for humans. SNPStats and OpenEpi software and Wilcoxon's U test were used to perform statistical analysis. IL16 rs11556218 polymorphism was significantly associated to PD in nonsmoking patients: individuals with G/G genotype were less likely to develop PD compared to the T/T genotype (OR = 0.10; Pc = 0.019, codominant model). In addition, the TTT haplotype was associated with a high risk for PD (OR = 2.45; P = 0.01). A low IL-16 serum level was observed among individuals with PD when compared to controls (P = 0.027). Thus, the IL16 rs16556218 polymorphism and the serum levels of IL-16 were associated with periodontitis in a Brazilian sample, and this was influenced by environmental factors such as smoking.

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Interleukin-16 Gene Polymorphisms rs4778889, rs4072111, rs11556218, and Cancer Risk in Asian Populations: A Meta-Analysis

Abstract: The rs11556218 T/G polymorphism of the IL-16 gene was significantly associated with elevated cancer risk in Asian populations. Our results warrant larger, better-designed studies, including a greater ethnic variety.

Cited by 10 publications

References 23 publications

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

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