Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts

Abstract

These results suggest that IL-17 is an in vitro stimulator of angiogenic factor release, both by its own action and by cooperating with TNF-alpha.

Protumor vs Antitumor Functions of IL-17

“…Moreover, the levels of Th17 cells were positively correlated with microvessel density in tumors (87). By acting on stromal cells and fibroblasts, IL-17 induces a wide range of angiogenic mediators (88,89), including vascular endothelial growth factor (VEGF), that markedly promote inflammatory and tumor angiogenesis (90). IL-17 is able to up-regulate VEGF production by fibroblasts and therefore promote fibroblast-induced new vessel formation in inflammation and tumors.…”

Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer

“…8 Since IL-6 and IL-23 are both involved in the IL-23/IL-17 pathway, in the present study we aimed to elucidate the role of IL-17 in cervical cancer. The function of IL-17 is tissue-and contextdependent and includes activation of nuclear factor-kB (NFkB), 9 vascular endothelial growth factor (VEGF) production and angiogenesis, [10][11][12][13][14] stimulation of pro-inflammatory cytokine production, 15 neutrophil recruitment, 16 and formation of epithelial tight junctions. 17 While it is clear that IL-17 plays a prominent role in both the protection of the host from invading extracellular pathogens and the destruction of host tissues in several chronic inflammatory and auto-immune disorders, there is controversy about its role in cancer.…”

The Overexpression of Heparin-Binding Epidermal Growth Factor Is Responsible for Th17-Induced Airway Remodeling in an Experimental Asthma Model

“…Heparin-binding EGF (HB-EGF), a potent mitogen and chemotactic factor for smooth muscle cells in the EGF family (14), is expressed mainly in the airway epithelium and is significantly upregulated in asthmatic airways (15). In vitro, there is also evidence that IL-17 can stimulate HB-EGF secretion by synovial fibroblasts (16). These observations led us to investigate the role of the EGFR pathway in Th17-related airway remodeling.…”