Interleukin-17 family members in health and disease

Abstract

The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and all the corresponding receptors have been identified recently. This family is mainly involved in the host defense mechanisms against bacteria, fungi and helminth infection by inducing cytokines and chemokines, recruiting neutrophils, inducing anti-microbial proteins and modifying T-helper cell differentiation. IL-17A and some other family cytokines are also involved in the development of psoriasis, psoriatic arthritis and ankylosing spondylitis by inducing inflammatory cytokines and chemokines, and antibodies against IL-17A as well as the receptor IL-17RA are being successfully used for the treatment of these diseases. Involvement in the development of inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and tumors has also been suggested in animal disease models. In this review, we will briefly review the mechanisms by which IL-17 cytokines are involved in the development of these diseases and discuss possible treatment of inflammatory diseases by targeting IL-17 family members.

The GT1-TPS Structural Domain Protein From Haemonchus contortus Could Be Suppressive Antigen of Goat PBMCs

“…Previous studies showed that Th1, Th2, Th9, and Th17 immune responses play important roles in fighting parasitic infections ( 47 – 50 ). Our results showed that rHc-TPS co-incubation with PBMCs significantly inhibited the transcriptional levels of IFN-γ, IL-4, and IL-9, which may exert one of the pathways of immune evasion.…”

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

“…The Th17 cell has been studied intensively in autoimmune diseases due to its capacity to induce inflammation. Its signature cytokines, including IL-17A and IL-17F, promote the production of proinflammatory molecules from various immune and non-immune cells, and recruit inflammatory cells—such as neutrophils and macrophages—to the inflammatory site [ 35 ]. Recent studies revealed that Th17 cells also express IL-24.…”

Interleukin-17 Can Be the Target of Novel Treatment Strategies for Particulate Matter–Induced Allergic Diseases

“…IL-17 affects tissue cells and IL-17 receptors are expressed in all epithelial cells. 12 IL-17 has related allergic responses and is elevated mainly in acute and severe forms of allergic diseases. 10 12 The IL-17 family consists of 6 members (IL17A to IL-17F).…”

“… 12 IL-17 has related allergic responses and is elevated mainly in acute and severe forms of allergic diseases. 10 12 The IL-17 family consists of 6 members (IL17A to IL-17F). The IL-17 receptors, IL-17RA, IL-17RB/IL-25R, IL-17RC, IL-17RD/SEF, and IL-17RE, play a role in the development and exacerbation of allergic diseases.…”

“…The IL-17 receptors, IL-17RA, IL-17RB/IL-25R, IL-17RC, IL-17RD/SEF, and IL-17RE, play a role in the development and exacerbation of allergic diseases. 12 13 14 Anti-IL-17 therapy has been proposed to be promising for asthma patients. 15 IL-17 increases the levels of proinflammatory and profibrotic cytokines.…”