Interleukin-17A correlates with interleukin-6 production in human cystic echinococcosis: a possible involvement of IL-17A in immunoprotection against Echinococcus granulosus infection

Mezioug, Dalila; Touil-Boukoffa, Chafia

doi:10.1684/ecn.2012.0314

Cited by 41 publications

(30 citation statements)

References 64 publications

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“…2a, b, the proportions of Th17 cells were significantly higher post-infection than those in the control group ( t (28) = -6.919, P < 0.001). This is consistent with previous data obtained from the study in patients [26]. In addition, the levels of proinflammatory cytokines in serum, such as IL-17A, IL-6, IFN-γ and TNF-α, were significantly increased post-infection ( t (28) = -2.852, P = 0.040; t (28) = -3.655, P = 0.036 and t (28) = -9.704, P = 0.001 and t (28) = -2.876, P = 0.039, respectively) (Fig.…”

Section: Resultssupporting

confidence: 94%

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The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells

et al. 2017

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BackgroundExcretory-secretory products (ESPs) released by helminths are well-known to regulate T cell responses in the host. However, their direct influence in the differentiation of naïve T cells, and especially B cells, remains largely unknown. This study investigated the effects of Echinococcus granulosus protoscoleces ESPs (EgPSC-ESPs) on the differentiation of IL-10-producing B cells (B10), IL-17A-producing B cells (B17) and Th17 cells.MethodsBALB/c mice injected with EgPSC were used to evaluate the in vivo profiles of B10, B17 and Th17 cells. In vitro purified CD19+ B and naïve CD4+ T cells were cultured in the presence of native, heat-inactivated or periodate-treated EgPSC-ESPs, and the differentiation of these cell subsets were compared.ResultsIn contrast to the control group, infected mice showed higher frequencies of B10, B17 and Th17 cells, and higher levels of IL-10 and IL-17A in the sera. Interestingly, B17 cells were first identified to express CD19+CD1dhigh. In vitro, B cells cultured with native ESPs exhibited a higher percentage of B10 cells but lower percentage of B17 and Th17 cells compared to the PBS group. Moreover, the relative expression of IL-10 and IL-17A mRNA were consistent with the altered frequencies. However, ESPs subjected to heat-inactivation or periodate treatment exhibited an inverse effect on the induction of these cell subsets.ConclusionsOur findings indicate that ESPs released by EgPSC can directly regulate the differentiation of B10, B17 and Th17 cells, which appear to be heat-labile and carbohydrate-dependent.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2263-9) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 94%

“…In accordance with the increased levels of IL-17A in the sera of CE patients [26], this study found significantly increased Th17 cell frequencies in infected mice. This effect may beneficial to the anti-parasite immune response.…”

Section: Discussionsupporting

confidence: 87%

The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells

et al. 2017

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“…Particularly, several findings demonstrated that pro-inflammatory cytokines have an important role in parasitic infections; in fact, increased serum Il-6, IFn-γ, Il-17a, and CrP levels have been found in hydatidosis patients [33]. On the other hand, in Trypanosoma cruzi-infected Il-17a-deficient mice, a lower post-infection survival rate and higher parasitemia were observed.…”

Section: Discussionmentioning

confidence: 99%

Neurocysticercosis: the effectiveness of the cysticidal treatment could be influenced by the host immunity

Cárdenas

Fragoso

Rosetti

et al. 2014

Med Microbiol Immunol

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Neurocysticercosis, a clinically and radiologically pleomorphic parasitic disease, is still endemic to most non-developed countries of Latin America, Africa, and Asia. Anti-helminthic drugs (AHD) are generally effective and rapidly destroy parenchymal cysticerci. In contrast, several cycles of AHD are frequently necessary to damage extraparenchymally located parasites. The present study was designed to evaluate whether differences in the immunological profile of the patients is involved in the diversity of the response to AHD. To this end, a global gene expression microarray and a cytokine analysis were made. Responder patients were those showing a radiological reduction greater than 50 % in the parasite burden following AHD treatment. Microarray pre- and post-treatment comparisons showed that a total of eighteen immune-related genes were up-regulated in the five responder patients with respect the expression profile seen in the four non-responder subjects. The function of up-regulated genes exerted pro-inflammatory (RORγC, Sema4A, SLAMF3, SLAMF6), anti-inflammatory (TGFβ, TNFRSF25, TNFRS18, SLAMF1, ILF2), or immunomodulatory effects (CXCL2, RUNX3, SLAMF9, TGFBR3). To further explore the causes of the heterogeneity in the response to treatment, a wide ELISA cytokine analysis was performed in serum, PBMC supernatants, and CSF samples from 39 responder and 26 non-responder patients. Responder patients showed higher CSF IL-17A levels (P = 0.04) and higher supernatant IL-6 levels (P = 0.03) 60 days after treatment. These results suggest a possible influence of pro-inflammatory cytokines on the response to AHD as observed by radiological methods, and thus the possible participation of the host immunity in the effectiveness of AHD treatment.

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“…Infection studies demonstrate that Th17 cells mediate host defense against Trypanosoma cruzi 105 , Toxoplasma gondii 106 , Leishmania braziliensis 107 , and Echinococcus granulosus 108 infections. NK cells are a major source of IL-17 during toxoplasmosis 32 .…”

Section: Role Of Il-17 In Parasitic Infectionmentioning

confidence: 99%

Yin and yang of interleukin-17 in host immunity to infection

Das

Khader

2017

F1000Res

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The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.

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Interleukin-17A correlates with interleukin-6 production in human cystic echinococcosis: a possible involvement of IL-17A in immunoprotection against Echinococcus granulosus infection

Cited by 41 publications

References 64 publications

The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells

The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells

Neurocysticercosis: the effectiveness of the cysticidal treatment could be influenced by the host immunity

Yin and yang of interleukin-17 in host immunity to infection

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