2010
DOI: 10.1128/iai.00385-10
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Interleukin-17A during Local and SystemicStaphylococcus aureus-Induced Arthritis in Mice

Abstract: Staphylococcus aureus is one of the dominant pathogens that induce septic arthritis in immunocompromised hosts, e.g., patients suffering from rheumatoid arthritis treated with immunosuppressive drugs. S. aureus-induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Recently, interleukin-17A (IL-17A) has been discovered to be an important mediator of aseptic arthritis both in mice and humans, but its function in S. aureus-induced arthritis is largely unknown. Here, … Show more

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Cited by 29 publications
(30 citation statements)
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“…6A and C), mitigation of the general inflammatory condition (Fig. 7B) and, in particular, decreasing levels of IL-17, which have been shown to be directly involved in the development of arthritis after bacterial infection65. Interestingly, the protection experiment performed with the bioluminescent Xen36 strain suggested that local reduction of bacteria observed in the joints was dependent on the induction of an efficacious local immune response, rather than to the lower number of bacteria reaching the joints due to systemic neutralization (Fig.…”
Section: Discussionmentioning
confidence: 94%
“…6A and C), mitigation of the general inflammatory condition (Fig. 7B) and, in particular, decreasing levels of IL-17, which have been shown to be directly involved in the development of arthritis after bacterial infection65. Interestingly, the protection experiment performed with the bioluminescent Xen36 strain suggested that local reduction of bacteria observed in the joints was dependent on the induction of an efficacious local immune response, rather than to the lower number of bacteria reaching the joints due to systemic neutralization (Fig.…”
Section: Discussionmentioning
confidence: 94%
“…The lower IL-17A levels could possibly contribute to the observed higher bacterial loads in RAGE deficient mice since the recruitment of cells to clear the bacteria might have been affected. However, in a previous study by Henningsson et al , differences in terms of severity and frequency of clinical arthritis, mortality and bacterial loads at majority of the time points were not detected between the IL-17A deficient and wild-type mice [33], suggesting that lack of IL-17A during systemic infection with S . aureus has limited impact.…”
Section: Discussionmentioning
confidence: 93%
“…However, IL-17A level was significantly lower in RAGE -/- mice. IL-17A is a potent pro-inflammatory cytokine that is involved in elimination of extracellular bacteria [33]. It induces the production of neutrophil- and macrophage stimulating growth factors and neutrophil-mobilizing chemokines that in turn leads to mobilization of neutrophils into the site of infection.…”
Section: Discussionmentioning
confidence: 99%
“…Our focus on the Th17 response as a specific biological response pathway to intoxication was predicated on knowledge of the increased susceptibility of humans and mice lacking in this response to infection with S. aureus (48,63), the association of Th17 cells with the host response to S. aureus (14,23,26,31,40), and the more recent findings from Niebuhr and colleagues that S. aureus Hla induced IL-17A in peripheral blood mononuclear cells and Th17 cells in the setting of atopic dermatitis (55).…”
Section: Discussionmentioning
confidence: 99%