Interleukin-17A in &lt;i&gt;Legionella&lt;/i&gt; pneumonia: A Retrospective Study

Higa, Futoshi; Haroon, Attiya; Iha, Yoshikazu; Tasato, Daisuke; Nakamura, Hideta; Kinjo, Takeshi; Tamayose, Maki; Furugen, Makoto; Miyagi, Kazuya; Haranaga, Shusaku; Tateyama, Masao; Fujita, Jiro

doi:10.7883/yoken.jjid.2014.171

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…It has been proven that IL-17A has a protective role in host defense against airway pathogens in mice, but it is also involved in the local and systemic immune response in human pneumonia [27,28]. In a recent study, F. Higa et al postulated that this cytokine might play a role in legionnaire disease [29]. M.S.…”

Section: Discussionmentioning

confidence: 99%

Systemic interleukins levels in community-acquired pneumonia and their association with adverse outcomes

Tripon

Berindan‐Neagoe

Budişan

et al. 2019

Revista Romana De Medicina De Laborator

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Introduction: Community-acquired pneumonia (CAP) is still one of the major causes of morbidity and mortality worldwide. Pro-inflammatory and anti-inflammatory interleukins have been studied to elucidate the role that inflammation plays in its pathogenesis. The aim of this study is to investigate inflammation in CAP, by analyzing in dynamic, serum levels of six interleukins (IL) and their predictive value regarding adverse outcomes. Materials and methods: Forty adult patients with CAP, admitted in the Teaching Hospital of Infectious Diseases, Cluj-Napoca, Romania from December 2015 to February 2017, were enrolled in this study. Serum levels of pro-inflammatory: IL1β, TNF-α, IL-6, anti-inflammatory: IL-10 and IL-4, along with IL-17A were analyzed in dynamic, on day 1 and day 4.The receiver – operator curves (ROC) were used to analyze the outcome prediction of IL. Results: Serum levels of IL-1β, IL-6, TNF-α and IL-10 have decreased significantly in dynamic, while IL-4 increases. IL-17A has acted like a pro-inflammatory cytokine. We have found a correlation between IL-6 and IL-10 (r=0.429, p=0.000), IL-6 and IL-17A (r=0.295, p=0.008) and IL-10 and IL-17A (r=0.475, p=0.000). Out of 40 patients, 9 had adverse outcomes, consisting in 9 relapses from which 1 died. IL-6 discriminates alone between adverse and favorable outcomes. With multivariate analysis and multiple regression of all combined IL, we have found that there is a predictive model regarding adverse outcomes. Conclusion: IL-10 and IL-17A behave like pro-inflammatory cytokines. IL-6 is a predictive marker for adverse outcomes alone. All IL studied together have an impact on adverse outcomes.

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Section: Discussionmentioning

confidence: 99%

Systemic interleukins levels in community-acquired pneumonia and their association with adverse outcomes

Tripon

Berindan‐Neagoe

Budişan

et al. 2019

Revista Romana De Medicina De Laborator

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Viewing Legionella pneumophila Pathogenesis through an Immunological Lens

Liu

Shin

2019

Journal of Molecular Biology

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Clinical and Laboratory Diagnosis of Legionella Pneumonia

Bai

Yang

2023

Diagnostics

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Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do not meet the clinical need for rapid and accurate diagnosis, especially for critically ill patients. So far, pathogenic detection techniques including serological assays, urinary antigen tests, and mass spectrometry, as well as nucleic acid amplification technique, have been developed, and each has its own advantages and limitations. This review summarizes the clinical characteristics and imaging findings of Legionella pneumonia, then discusses the advances, advantages, and limitations of the various pathogenetic detection techniques used for Legionella pneumonia diagnosis. The aim is to provide rapid and accurate guiding options for early identification and diagnosis of Legionella pneumonia in clinical practice, further easing healthcare burden.

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Interleukin-17A in <i>Legionella</i> pneumonia: A Retrospective Study

Cited by 3 publications

References 12 publications

Systemic interleukins levels in community-acquired pneumonia and their association with adverse outcomes

Systemic interleukins levels in community-acquired pneumonia and their association with adverse outcomes

Viewing Legionella pneumophila Pathogenesis through an Immunological Lens

Clinical and Laboratory Diagnosis of Legionella Pneumonia

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